POINT-COUNTERPOINT: What is the optimal trial design to test hyperthermia for carcinoma of the cervix? POINT: Addition of hyperthermia or cisplatin to radiotherapy for patients with cervical cancer; two promising combinations--no definite conclusions
POINT-COUNTERPOINT: What is the optimal trial design to test hyperthermia for carcinoma of the cervix? POINT: Addition of hyperthermia or cisplatin to radiotherapy for patients with cervical cancer; two promising combinations--no definite conclusions
复制标题
点对点：测试宫颈癌热疗的最佳试验设计是什么？
DOI：
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发表时间：
2002
影响因子：
3.1
通讯作者：
C. Burger
中科院分区：
文献类型：
--
作者：
J. Zee;P. Koper;L. Lutgens;C. Burger
随机试验表明，宫颈癌患者的放疗结果可以通过联合顺铂化疗或热疗来改善。放疗联合化疗和放疗联合热疗的研究，有几个重要的问题没有得到解答。目前还没有明确的结论可以得出哪种组合产生最佳的治疗比例。因此，在伦理和科学的基础上，下一个合乎逻辑的步骤将是以随机的方式比较两种类型的联合治疗，以及每种组合治疗包括所有三种模式。
Randomized trials have shown that results of radiotherapy in patients with cervical cancer can be improved by combining the treatment with either cisplatin based chemotherapy, or hyperthermia. The studies on both the combination of radiotherapy with chemotherapy, and the combination on radiotherapy with hyperthermia, leave several important questions unanswered. At present, no definite conclusions can be drawn with regard to which combination results in the best therapeutic ratio. Therefore, on both ethical and scientific grounds, the next logical step would be to compare the two types of combined treatment to each other, and each combination with a treatment including all three modalities, in a randomized fashion.
DOI：
10.1097/00006254-200008000-00017
发表时间：
2000-04
期刊：
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
影响因子：
--
作者：
W. Peters;P. Liu;R. Barrett;R. Stock;B. Monk;J. Berek;L. Souhami;P. Grigsby;W. Gordon;
通讯作者：
W. Peters;P. Liu;R. Barrett;R. Stock;B. Monk;J. Berek;L. Souhami;P. Grigsby;W. Gordon;
影响因子：
158.5
作者：
Keys, HM;Bundy, BN;Gersell, D
通讯作者：
Gersell, D
影响因子：
158.5
作者：
Rose, PG;Bundy, BN;Insalaco, S
通讯作者：
Insalaco, S