Pancreas ductal adenocarcinoma with cystic features on cross-sectional imaging: radiologic-pathologic correlation
Pancreas ductal adenocarcinoma with cystic features on cross-sectional imaging: radiologic-pathologic correlation
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DOI：
10.5152/dir.2018.17250
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发表时间：
2018-01-01
影响因子：
2.1
通讯作者：
Lee, In Seok
中科院分区：
文献类型：
--
作者：
Youn, Seo Yeon;Rha, Sung Eun;Lee, In Seok
大多数胰腺导管腺癌(PDA)表现为实性生长，但导管腺癌可表现为瘤内囊性表现或伴有瘤周非肿瘤性囊性病变，从而在影像上类似于囊性胰腺肿瘤。囊性PDA的组织病理学表现分为肿瘤性和非肿瘤性。肿瘤性囊变包括大管型(微囊型)、肿瘤性粘液囊性(巨囊型)、胶样癌(粘液性非囊性腺癌)，以及通常由肿瘤出血性坏死引起的退行性囊性变。非肿瘤性囊性改变包括由导管阻塞引起的滞留性囊变和由肿瘤相关性胰腺炎引起的假性囊性变。根据囊性病变的存在、大小、数量和形态，PDA应与不同类型的囊性肿瘤相鉴别。这篇图片文章提供了具有囊性特征的PDA的组织病理学分类以及相应的横断面影像表现，以及它们的鉴别诊断。
Most pancreatic ductal adenocarcinomas (PDAs) show solid growth pattern, but ductal adenocarcinomas may demonstrate intratumoral cystic appearance or accompany peritumoral non-neoplastic cystic lesions, thus mimicking cystic pancreatic tumors on imaging studies. The histopathologic findings for PDA with cystic feature are divided into neoplastic and non-neoplastic cysts. Neoplastic cystic changes include large-duct type cysts (microcystic appearance), neoplastic mucin cysts (macrocystic appearance), colloid carcinomas (mucinous noncystic adenocarcinomas), and degenerative cystic change usually caused by hemorrhagic necrosis of tumor. Non-neoplastic cystic changes include retention cysts caused by ductal obstruction and pseudocysts caused by tumor-associated pancreatitis. Depending on the presence, size, number, and configuration of cystic changes, PDA should be differentiated from various types of cystic neoplasms. This pictorial essay provides histopathologic classification of PDAs with cystic features along with the corresponding cross-sectional imaging findings, and their differential diagnosis.