Gut-homing (α4β7+) Th1 memory responses after inactivated poliovirus immunization in poliovirus orally pre-immunized donors
Gut-homing (α4β7+) Th1 memory responses after inactivated poliovirus immunization in poliovirus orally pre-immunized donors
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DOI：
10.1099/vir.0.79919-0
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发表时间：
2004-06-01
影响因子：
3.8
通讯作者：
Meyerhans, A
中科院分区：
文献类型：
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作者：
Krieg, C;Maier, R;Meyerhans, A
粘液瘤感染由专门的局部免疫系统预防。该区室的免疫细胞也可以在血液中发现，并且其特征在于表达粘膜特异性归巢分子。在此，研究了脊髓灰质炎病毒口服预免疫供体中灭活脊髓灰质炎病毒免疫（IPV）后的细胞免疫应答。皮下IPV诱导了对脊髓灰质炎病毒抗原的增殖反应和疫苗接种者血液中脊髓灰质炎病毒特异性CD 4（+）T细胞数量的短暂增加。这些细胞被表征为效应记忆型（CD 45 RA（-）/CD 45 RO（+）/CCR 7（-）/CD 27（+）），并表达归巢分子α（4）β（7），表明它们来源于肠道。这些数据共同显示了肠源性脊髓灰质炎病毒特异性细胞在IPV后的复发，并评价了全血测定作为监测疫苗接种成功的有力工具。
Mucosal infections are prevented by a specialized local immune system. Immune cells of this compartment can also be found in the blood and are characterized by the expression of mucosa-specific homing molecules. Here, the cellular immune responses after inactivated poliovirus immunization (IPV) in poliovirus orally pre-immunized donors were investigated. Subcutaneous IPV induced a transient increase in the proliferative response against poliovirus antigen and in the number of poliovirus-specific CD4(+) T cells in the blood of the vaccinees. These cells were characterized to be of the effector memory type (CD45RA(-)/CD45RO(+)/CCR7(-)/CD27(+)) and expressed the homing molecule alpha(4)beta(7), indicating their origin from the gut. Together these data show the recurrence of gut-derived poliovirus-specific cells upon IPV and evaluate the whole-blood assay as a powerful tool for monitoring the success of a vaccination.