Quality of life in oral carcinoma: A 5-year prospective study
Quality of life in oral carcinoma: A 5-year prospective study
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DOI：
10.1002/hed.20735
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发表时间：
2008-04-01
影响因子：
2.9
通讯作者：
Jannert, Magnus
中科院分区：
文献类型：
--
作者：
Nordgren, Mats;Hammerlid, Eva;Jannert, Magnus
背景资料。我们进行了这项前瞻性多中心研究，以评估口腔癌患者在确诊时、1年后和5年后的健康相关生活质量(HRQL)与肿瘤部位和治疗方式的关系。对122例口腔癌患者(平均年龄61岁，男性占62%)进行了标准化生活质量调查问卷、欧洲癌症研究与治疗组织生活质量问卷核心30(EORTC QLQ-C30)和EORTC头颈部癌症模块(EORTC QLQ-H&N35)的评估。从确诊到确诊5年后，牙齿、口干和唾液粘稠的问题变得更严重。除了仅接受手术治疗的患者外，口干问题在确诊后1至5年内仍然是一个问题。与接受其他治疗方案的患者相比，随着时间的推移，这组患者的问题较少。幸存者在确诊时和一年的随访中报告的HRQL比死亡者更好。确诊时的HRQL与生存相关。口腔癌患者确诊时的HRQL似乎是影响HRQL长期预后和生存的重要因素。口腔癌的治疗通常会导致长期的副作用，如口干、牙齿问题和唾液粘稠。(C)2007年威利期刊公司。
Background. We conducted this prospective longitudinal multicenter study to evaluate the health-related quality of life (HRQL) of patients with oral carcinoma at diagnosis, and after 1 and 5 years in relation to tumour location and treatment modality.Methods. One hundred twenty-two patients (mean age, 61; 62% males) with oral carcinoma were evaluated with standardized HRQL questionnaires, the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core30 (EORTC QLQ-C30) and the EORTC Head and Neck Cancer Module (EORTC QLQ-H&N35).Results. Problems with teeth, dry mouth, and sticky saliva got worse between diagnosis and 5 years after diagnosis. Problems with dry mouth remained a problem between 1 and 5 years after diagnosis, except for the patients treated with surgery only. This group had fewer problems over time compared with patients receiving other treatment regimes. Survivors reported better HRQL than the nonsurvivors at diagnosis and at the 1-year follow-up. HRQL at diagnosis was associated with survival.Conclusions. HRQL at diagnosis for patients with oral carcinoma seems to be an important factor for the prognosis of both HRQL over time and survival. Treatment of oral carcinoma often results in long-term side effects such as dry mouth, problems with teeth, and sticky saliva. (C) 2007 Wiley Periodicals, Inc.