Model-based lesion mapping of cognitive control using the Wisconsin Card Sorting Test
Model-based lesion mapping of cognitive control using the Wisconsin Card Sorting Test
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DOI：
10.1038/s41467-018-07912-5
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发表时间：
2019-01-03
影响因子：
16.6
通讯作者：
Tranel, Daniel
中科院分区：
文献类型：
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作者：
Glaescher, Jan;Adolphs, Ralph;Tranel, Daniel
额叶在认知和行为中的作用一直是个谜。在过去的十年中，计算模型为理解认知和决策提供了一种强有力的方法。在这里，我们使用了基于模型的方法来分析数据，从一个经典的任务，用于评估额叶功能，威斯康星州卡片分类测试。我们应用计算建模和基于体素的病灶症状映射在328例局灶性病变，以揭示认知过程和神经相关的测试分数。我们的研究结果表明，右前额叶皮层的病变与持续错误的增加和对惩罚敏感性的模型参数的减少有关。这些发现表明，在任务集之间灵活切换的能力需要检测偶然性变化，而这是通过对惩罚的敏感性来实现的，从而减少持续性错误。我们展示了基于模型的方法在理解经典神经心理学任务的缺陷模式中的作用。
The role of the frontal lobes in cognition and behavior has long been enigmatic. Over the past decade, computational models have provided a powerful approach to understanding cognition and decision-making. Here, we used a model-based approach to analyze data from a classical task used to assess frontal lobe function, the Wisconsin Card Sorting Test. We applied computational modeling and voxel-based lesion-symptom mapping in 328 patients with focal lesions, to uncover cognitive processes and neural correlates of test scores. Our results reveal that lesions in the right prefrontal cortex are associated with elevated perseverative errors and reductions in the model parameter of sensitivity to punishment. These findings indicate that the capacity to flexibly switch between task sets requires the detection of contingency changes, which are enabled by a sensitivity to punishment that reduces perseverative errors. We demonstrate the power of model-based approaches in understanding patterns of deficits on classical neuropsychological tasks.