Results of a pilot study of low‐dose craniospinal radiation therapy plus chemotherapy for children younger than 5 years with primitive neuroectodermal tumors
Results of a pilot study of low‐dose craniospinal radiation therapy plus chemotherapy for children younger than 5 years with primitive neuroectodermal tumors
复制标题
低剂量颅脊髓放射治疗联合化疗治疗 5 岁以下原始神经外胚层肿瘤儿童的初步研究结果
作者：
J. Goldwein;J. Radcliffe;R. Packer;L. Sutton;B. Lange;L. Rorke;G. D'angio
背景。 5 岁以下患有后颅窝 (PF) 原始神经外胚层肿瘤 (PNET) 的儿童预后较差。由于单独使用低剂量颅脊髓放射治疗 (CSRT) 与这些患者较高的复发率相关，而且标准剂量 CSRT 与严重的晚期后遗症相关，因此作者开始了一项联合使用低剂量 CSRT 和辅助化疗的研究。
Background. Children younger than 5 years who have posterior fossa (PF) primitive neuroectodermal tumors (PNET) have a poor prognosis. Because the use of low‐dose craniospinal radiation therapy (CSRT) alone has been associated with a higher relapse rate in these patients, and because standard dose CSRT is associated with profound late sequelae, the authors embarked on a study using a combination of low‐dose CSRT and adjuvant chemotherapy.
使用丙卡巴肼、羟基脲治疗髓母细胞瘤，并减少全脑和脊柱的辐射剂量。
影响因子：
4.1
作者：
Levin,VA;Rodriguez,LA;Edwards,MS;Wara,W;Liu,HC;Fulton,D;Davis,RL;Wilson,CB;Silver,P
通讯作者：
Silver,P