Transmission of chronic nociception by spinal neurons expressing the substance P receptor
Transmission of chronic nociception by spinal neurons expressing the substance P receptor
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DOI：
10.1126/science.286.5444.1558
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发表时间：
1999-11-19
期刊：
影响因子：
56.9
通讯作者：
Mantyh, PW
中科院分区：
文献类型：
--
作者：
Nichols, ML;Allen, BJ;Mantyh, PW
用选择性细胞毒素P皂苷物质消融表达P物质受体的脊髓神经元。这些神经元的丢失导致与持续性神经性和炎症性疼痛状态相关的热痛觉过敏和机械异常痛的减少。这种损失似乎是永久性的。对轻度疼痛刺激和吗啡镇痛的反应不受这种治疗的影响。这些结果确定了治疗持续性疼痛的靶点，并表明脊髓背角中表达spr的少量神经元在慢性神经性和炎症性疼痛的产生和维持中起着关键作用。
Substance P receptor (SPR)-expressing spinal neurons were ablated with the selective cytotoxin substance P-saporin. Loss of these neurons resulted in a reduction of thermal hyperalgesia and mechanical allodynia associated with persistent neuropathic and inflammatory pain states. This Loss appeared to be permanent. Responses to mildly painful stimuli and morphine analgesia were unaffected by this treatment. These results identify a target for treating persistent pain and suggest that the small population of SPR-expressing neurons in the dorsal horn of the spinal cord plays a pivotal role in the generation and maintenance of chronic neuropathic and inflammatory pain.