Comparison of toluene-induced and styrene-induced hearing losses
Comparison of toluene-induced and styrene-induced hearing losses
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DOI：
10.1016/s0892-0362(99)00030-6
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发表时间：
1999-11-01
影响因子：
2.9
通讯作者：
Lataye, R
中科院分区：
文献类型：
--
作者：
Loquet, G;Campo, P;Lataye, R
甲苯和苯乙烯是工业溶剂，会严重损害成年大鼠的听觉功能。在本研究中，根据相同的时间表调查了甲苯（1000至2000 ppm）和苯乙烯（500至1500 ppm）剂量：每天6小时，每周5天，连续4周。通过记录下丘在2 ~ 32 kHz频率范围内的诱发电位来测试动物的听觉功能，而病理数据则通过常规组织学技术进行评估。当苯乙烯剂量比甲苯剂量低2.4倍时，获得了永久阈值位移（PTS）。在相同的实验条件下，苯乙烯的回归线斜率（PTS/剂量）比甲苯的斜率大2.1。沿Corti器官的组织病理学事件顺序，特别是创伤的有序性和位置，在苯乙烯和甲苯的配对浓度下是相似的，第一次匹配分别为650 ppm， 1500 ppm，第二次匹配分别为850 ppm， 1750 ppm。电生理和组织学结果都指出苯乙烯的耳毒性比甲苯高。本文讨论了有关耳毒性机制的假设。(C) 1999 Elsevier Science Inc.；版权所有。
Toluene and styrene are industrial solvents that can severely damage the auditory function in adult rats. In the present study, toluene (1000 to 2000 ppm) and styrene doses (500 to 1500 ppm) were investigated according to the same schedule: 6 hours per day, 5 days per week, for 4 consecutive weeks. The auditory function of the animals was tested by recording evoked potentials from the inferior colliculus over a frequency range from 2 to 32 kHz, whereas pathological data were evaluated by conventional histologic techniques. The permanent threshold shifts (PTS) were obtained with a styrene dose 2.4 times lower than that of the toluene. The slope of the regression line (PTS/doses) was 2.1 steeper with styrene than that obtained with toluene in the same experimental conditions. The sequence of histopathological events along the organ of Corti, especially the orderliness and the location of the traumas, was similar for paired concentrations of styrene and toluene, which were respectively 650 ppm, 1500 ppm for the first match, and 850 ppm, 1750 ppm for the second one. Both electrophysiological and histological findings point out the higher ototoxic potency of the styrene compared to that of the toluene. Assumptions concerning the ototoxic mechanism are addressed in the present paper. (C) 1999 Elsevier Science Inc. All rights reserved.