Lipid droplet proteins and metabolic diseases
Lipid droplet proteins and metabolic diseases
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DOI：
10.1016/j.bbadis.2017.07.019
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发表时间：
2018-05-01
影响因子：
6.2
通讯作者：
Liu, Pingsheng
中科院分区：
文献类型：
--
作者：
Xu, Shimeng;Zhang, Xuelin;Liu, Pingsheng
脂滴是细胞内普遍存在的储存脂质的细胞器，由中性脂质核和蛋白质修饰的磷脂单层构成。虽然脂质储存是它们最明显的功能，但LD远非惰性的，因为它们通过脂质合成、代谢和运输参与维持脂质稳态。此外，它们参与细胞信号传导和与人类疾病密切相关的其他分子事件，例如血脂异常、肥胖症、脂肪代谢障碍、糖尿病、脂肪肝、动脉粥样硬化等。在过去的十年里，人们对LD生物学的关注大大增加。无论如何，LD生物学的许多基本特征仍然模糊不清。在这篇综述中，我们将讨论LD生物学的关键方面，包括它们的生物起源，生长和退化。我们还将总结目前的知识LD在人类疾病中发挥的作用，特别是从相关蛋白质的动力学的角度。这篇文章是由Jan F.C.教授编辑的题为“心脏对肥胖、糖尿病和胰岛素抵抗的适应”的特刊的一部分。作者声明：Jason R.戴克和克莉丝汀·德·罗西尔斯。
Lipid droplets (LDs) are ubiquitous cellular organelles for lipid storage which are composed of a neutral lipid core bounded by a protein decorated phospholipid monolayer. Although lipid storage is their most obvious function, LDs are far from inert as they participate in maintaining lipid homeostasis through lipid synthesis, metabolism, and transportation. Furthermore, they are involved in cell signaling and other molecular events closely associated with human disease such as dyslipidemia, obesity, lipodystrophy, diabetes, fatty liver, atherosclerosis, and others. The last decade has seen a great increase in the attention paid to LD biology. Regardless, many fundamental features of LD biology remain obscure. In this review, we will discuss key aspects of LD biology including their biogenesis, growth and regression. We will also summarize the current knowledge about the role LDs play in human disease, especially from the perspective of the dynamics of the associated proteins. This article is part of a Special issue entitled Cardiac adaptations to obesity, diabetes and insulin resistance, edited by Professors Jan F.C. Glatz, Jason R.B. Dyck and Christine Des Rosiers.