Therapeutic manipulation of iNKT cells in autoimmunity: modes of action and potential risks
Therapeutic manipulation of iNKT cells in autoimmunity: modes of action and potential risks
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DOI：
10.1016/j.it.2004.07.001
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发表时间：
2004-09-01
影响因子：
16.8
通讯作者：
Lehuen, A
中科院分区：
文献类型：
--
作者：
Mars, LT;Novak, J;Lehuen, A
不变NKT （iNKT）细胞是一种独特的T细胞亚群，在激活后迅速产生大量的促炎性和抗炎性细胞因子，从而促进先天和获得性免疫。自身免疫性疾病的动物模型表明，iNKT细胞有利于免疫调节，因为在某些模型中，iNKT细胞的缺失增强了自身免疫，而iNKT细胞的富集则减轻了自身免疫表现。此外，聚合实验表明，靶向治疗iNKT细胞可以增强其免疫调节特性。因此，iNKT细胞被认为是治疗人类自身免疫性疾病的一个有吸引力的靶标。然而，在我们看来，在iNKT细胞操作可以安全地用于治疗自身免疫性疾病患者之前，必须解决几个问题。在这里，我们讨论这种方法的治疗潜力，以及它可能存在的缺陷。
Invariant NKT (iNKT) cells are a unique T cell subset that upon activation promptly produce copious amounts of pro- and anti-inflammatory cytokines, thereby contributing to both innate and acquired immunity. Animal models of autoimmune diseases suggest that iNKT cells favor immune regulation because their absence enhances autoimmunity in some models, whereas their enrichment alleviates autoimmune manifestations. Moreover, convergent experiments indicate that therapeutic targeting of iNKT cells can potentiate their immunoregulatory properties. Therefore, iNKT cells are considered an attractive target for the treatment of human autoimmune disorders. However, in our opinion several concerns must be addressed before iNKT cell manipulation can be safely used for treating patients with autoimmune diseases. Here, we discuss the therapeutic potential of this approach, and its possible pitfalls.