100% adherence study: educational workshops vs. video sessions to improve adherence among ART-naive patients in Salvador, Brazil.
100% adherence study: educational workshops vs. video sessions to improve adherence among ART-naive patients in Salvador, Brazil.
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100%%20依从性%20研究：%20教育%20研讨会%20vs.%20视频%20会话%20至%20改善%20依从性%20其中%20ART-naive%20患者%20in%20萨尔瓦多，%20巴西。
DOI：
10.1007/s10461-008-9414-0
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发表时间：
2008
影响因子：
4.4
通讯作者：
Brites,Carlos
中科院分区：
文献类型：
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作者：
Sampaio-Sa,Marcia;Page-Shafer,Kimberly;Bangsberg,DavidR;Evans,Jennifer;Dourado,MariadeLourdes;Teixeira,Celia;Netto,EduardoM;Brites,Carlos
我们在巴西萨尔瓦多进行了一项随机试验，以测试一种干预措施，旨在提高艾滋病毒阳性、抗逆转录病毒治疗（ART）初治患者对ART的依从性。参与者（N= 107）被随机分配到基于信息-动机-行为技能模型的教育研讨会（n= 52）或对照视频会议（n= 55）。在12个月内定期测量自我报告的ART依从性、病毒载量、CD 4细胞计数和ART药房记录的变化。3-6个月后，工作坊组和视频组的ART依从性（≥95%）分别为77.8%和85.7使用意向治疗（ITT）分析，分别为53.8%和65.5%（均P> 0.05）在9-12个月时，ART依从性在车间组和视频组分别下降到73.7%和79.1%（治疗），ITT分别为53.8%和61.8%。两组之间的自我报告依从性、病毒载量或药房记录无差异。我们发现，教育研讨会的干预并没有增加对ART的依从性。
We conducted a randomized trial to test an intervention aimed at increasing adherence to antiretroviral therapy (ART) among HIV-positive, ART-naïve patients in Salvador, Brazil. Participants (N= 107) were randomized to either educational workshops based on the information-motivation-behavioral skills model (n= 52) or a control video session (n= 55). Changes in self-reported ART adherence, viral load, CD4 cell counts and ART pharmacy records were measured periodically over 12 months. After 3–6 months, ART adherence (≥95%) was 77.8% in the workshop group and 85.7% in video group (as treated) and 53.8% and 65.5%, respectively, using intention-to-treat (ITT) analysis (bothP> 0.05) At 9–12 months, ART adherence decreased to 73.7% in the workshop group and 79.1% in the video group (as treated) and 53.8% and 61.8% using ITT, respectively. No differences were found in self-reported adherence, viral load or pharmacy records between groups. We found that the educational workshop intervention does not increase adherence to ART.