Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis
Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis
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DOI：
10.3945/ajcn.110.001917
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发表时间：
2011-04-01
影响因子：
7.1
通讯作者：
Auwerx, Johan
中科院分区：
文献类型：
--
作者：
Fernandez-Marcos, Pablo J.;Auwerx, Johan
负责细胞和整个生物体中能量管理的机制需要复杂的转录因子和辅因子网络。过氧化物酶体增殖物激活受体γ共激活因子1 α（PGC-1 α）已成为线粒体生物发生和功能的主要调节因子，因此成为关键的代谢节点。我们提出了PGC-1 α的调控机制的概述，包括PGC-1 α表达的转录调控和通过翻译后修饰微调其最终活性。美国临床营养杂志2011; 93（增刊）：884S-90S。
Mechanisms responsible for energy management in the cell and in the whole organism require a complex network of transcription factors and cofactors. Peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha) has emerged as a master regulator of mitochondrial biogenesis and function, thus becoming a crucial metabolic node. We present an overview of the mechanisms by which PGC-1 alpha is regulated, including the transcriptional regulation of PGC-1 alpha expression and the fine-tuning of its final activity via posttranslational modifications. Am J Clin Nutr 2011; 93 (suppl):884S-90S.