Malaria Rapid Diagnostic Tests
Malaria Rapid Diagnostic Tests
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DOI：
10.1093/cid/cis228
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发表时间：
2012-06-01
影响因子：
11.8
通讯作者：
Wilson, Michael L.
中科院分区：
文献类型：
--
作者：
Wilson, Michael L.
控制疟疾的全球努力比控制其他传染病的努力更为复杂，部分原因是病媒传播、疟原虫感染的复杂临床表现、> 1种疟原虫引起感染、病媒和感染的地理分布以及耐药性。世界卫生组织的全球疟疾控制方法侧重于两个组成部分：病媒控制和临床疟疾的诊断和治疗。尽管对外周血涂片进行的显微镜检查仍然是最广泛使用的诊断测试和衡量其他测试的标准，但全球诊断测试的快速扩展将需要使用其他诊断方法。本综述将重点介绍用于检测疟疾寄生虫血症的疟疾快速诊断试验（MRDT），包括MRDT的性能特点以及在现场条件下的使用方法。重点将放在疟疾流行地区，特别是与疟疾有关的死亡最多的撒哈拉以南非洲地区的监测和诊断技术的性能和使用。
Global efforts to control malaria are more complex than those for other infectious diseases, in part because of vector transmission, the complex clinical presentation of Plasmodium infections, > 1 Plasmodium species causing infection, geographic distribution of vectors and infection, and drug resistance. The World Health Organization approach to global malaria control focuses on 2 components: vector control and diagnosis and treatment of clinical malaria. Although microscopy performed on peripheral blood smears remains the most widely used diagnostic test and the standard against which other tests are measured, rapid expansion of diagnostic testing worldwide will require use of other diagnostic approaches. This review will focus on the malaria rapid diagnostic test (MRDT) for detecting malaria parasitemia, both in terms of performance characteristics of MRDTs and how they are used under field conditions. The emphasis will be on the performance and use of MRDTs in regions of endemicity, particularly sub-Saharan Africa, where most malaria-related deaths occur.