Alternative splicing for diseases, cancers, drugs, and databases.
Alternative splicing for diseases, cancers, drugs, and databases.
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DOI：
10.1155/2013/703568
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发表时间：
2013
影响因子：
--
通讯作者：
Chang HW
中科院分区：
文献类型：
--
作者：
Tang JY;Lee JC;Hou MF;Wang CL;Chen CC;Huang HW;Chang HW
选择性剪接是人类转录组和蛋白质组的一种主要的多样化机制。包括癌症在内的几种疾病与选择性剪接的失调有关。因此，纠正选择性剪接可以恢复这些疾病患者的正常细胞生理学。本文综述了几种与剪接相关的疾病，包括癌症及其靶基因。由于新的抗癌药物往往靶向剪接体，一些临床药物和天然产物或其合成衍生物进行了分析，以确定其对选择性剪接的影响。还讨论了已知在癌症治疗期间对选择性剪接具有调节作用的其他药剂。同时也总结了几种常用的生物信息学资源。
Alternative splicing is a major diversification mechanism in the human transcriptome and proteome. Several diseases, including cancers, have been associated with dysregulation of alternative splicing. Thus, correcting alternative splicing may restore normal cell physiology in patients with these diseases. This paper summarizes several alternative splicing-related diseases, including cancers and their target genes. Since new cancer drugs often target spliceosomes, several clinical drugs and natural products or their synthesized derivatives were analyzed to determine their effects on alternative splicing. Other agents known to have modulating effects on alternative splicing during therapeutic treatment of cancer are also discussed. Several commonly used bioinformatics resources are also summarized.
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AltTrans：针对替代剪接和替代聚腺苷酸化的转录本模式变体。
影响因子：
3
作者：
Le Texier, V;Riethoven, JJ;Kumanduri, V;Gopalakrishnan, C;Lopez, F;Gautheret, D;Thanaraj, TA
通讯作者：
Thanaraj, TA
影响因子：
4.4
作者：
Floris, Matteo;Orsini, Massimiliano;Thanaraj, Thangavel Alphonse
通讯作者：
Thanaraj, Thangavel Alphonse
影响因子：
--
作者：
Fedorov O;Huber K;Eisenreich A;Filippakopoulos P;King O;Bullock AN;Szklarczyk D;Jensen LJ;Fabbro D;Trappe J;Rauch U;Bracher F;Knapp S
通讯作者：
Knapp S
影响因子：
5.8
作者：
Castrignano, T.;D'Antonio, M.;Pesole, G.
通讯作者：
Pesole, G.
影响因子：
6.8
作者：
Albert, Helene;Santos, Susana;Bagrel, Denyse
通讯作者：
Bagrel, Denyse