Age-related changes in cortical swallowing processing
Age-related changes in cortical swallowing processing
复制标题
皮质吞咽处理的年龄相关变化
DOI：
10.1016/j.neurobiolaging.2008.07.001
复制
发表时间：
2010
影响因子：
4.2
通讯作者：
R. Dziewas
中科院分区：
文献类型：
--
作者：
I. Teismann;O. Steinstraeter;W. Schwindt;E. Ringelstein;C. Pantev;R. Dziewas
吞咽的皮质组织主要在年轻和健康的受试者中被研究。衰老对人类吞咽的影响已在几项行为研究中被发现，并已知影响吞咽的口腔和咽部阶段。这项研究的目的是评估与年龄相关的吞咽障碍的潜在皮质代偿。对9名健康老年受试者(平均年龄71.6岁)和9名健康青年受试者(平均年龄23.8岁)进行了全头脑磁图检查。采用时-频图和合成孔径磁测法(SAM)对数据进行分析。使用排列检验对个体SAM数据进行分组分析。这项研究的主要发现是，与年轻对照组相比，老年受试者吞咽执行过程中躯体感觉皮质激活增加。这种影响在两个半球都存在。这些结果表明，在吞咽的复杂过程中，大脑随着年龄的增长而发生适应性变化。我们的发现强调了年龄匹配的对照组在与吞咽或其他复杂感觉运动过程相关的神经成像研究中的相关性。
The cortical organization of swallowing has been mainly studied in young and healthy subjects. Aging effects on human deglutition have been found in several behavioral studies and are known to affect both the oral and pharyngeal phases of swallowing. The aim of this study was to evaluate a potential cortical compensation of age-related swallowing impairment. Whole-head MEG was employed in 9 healthy elderly subjects (mean age 71.6 years) and compared to 9 healthy young participants (mean age 23.8 years). Data were analyzed by means of time–frequency plots and synthetic aperture magnetometry (SAM). Group analysis of individual SAM data was performed using a permutation test. The main finding of this study was an increase of somatosensory cortical activation during swallowing execution in elderly subjects compared to the young control group. This effect was present in both hemispheres. These results point to adaptive cerebral changes in response to aging effects on the complex process of swallowing. Our finding underlines the relevance of age matched control groups in neuroimaging studies related to deglutition or other complex sensorimotor processes.