INVOLVEMENT OF THE IRF-1 TRANSCRIPTION FACTOR IN ANTIVIRAL RESPONSES TO INTERFERONS
INVOLVEMENT OF THE IRF-1 TRANSCRIPTION FACTOR IN ANTIVIRAL RESPONSES TO INTERFERONS
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DOI：
10.1126/science.8009222
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发表时间：
1994-06-24
期刊：
影响因子：
56.9
通讯作者：
TANIGUCHI, T
中科院分区：
文献类型：
--
作者：
KIMURA, T;NAKAYAMA, K;TANIGUCHI, T
干扰素（IFN）诱导的抗病毒状态的机制还不清楚。干扰素调节因子-1（IRF-1）是一种IFN诱导的转录激活因子，而IRF-2抑制IRF-1的作用。在IRF-1基因无效突变小鼠（IRF-1（-/-）小鼠）细胞中，IFN-α（尤其是IFN-γ）对脑心肌炎病毒（EMCV）复制的抑制作用受损。IRF-1（-/-）小鼠对EMCV感染的抵抗力低于正常小鼠，表现为死亡率加快和靶器官中病毒滴度较大。IRF-1的缺失并没有明显影响其他两种病毒的复制。因此，IRF-1是IFN对某些病毒的抗病毒作用所必需的，但IFN通过不同的靶基因激活多种激活途径以诱导抗病毒状态。
The mechanisms underlying interferon (IFN)-induced antiviral states are not well understood. Interferon regulatory factor-1 (IRF-1) is an IFN-inducible transcriptional activator, whereas IRF-2 suppresses IRF-1 action. The inhibition of encephalomyocarditis virus (EMCV) replication by IFN-alpha and especially by IFN-gamma was impaired in cells from mice with a null mutation in the IRF-1 gene (IRF-1(-/-) mice). The IRF-1(-/-) mice were less resistant than normal mice to EMCV infection, as revealed by accelerated mortality and a larger virus titer in target organs. The absence of IRF-1 did not clearly affect replication of two other types of viruses. Thus, IRF-1 is necessary for the antiviral action of IFNs against some viruses, but IFNs activate multiple activation pathways through diverse target genes to induce the antiviral state.