BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1
BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1
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DOI：
10.1038/ni944
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发表时间：
2003-07-01
影响因子：
30.5
通讯作者：
Murphy, KM
中科院分区：
文献类型：
--
作者：
Watanabe, N;Gavrieli, M;Murphy, KM
在激活过程中，T细胞表达接受正、负共刺激信号的受体。在这里，我们鉴定了B和T淋巴细胞衰减因子（BTLA），这是一种含有免疫球蛋白结构域的糖蛋白，具有两个基于酪氨酸的免疫受体抑制基元。初始T细胞不表达BTLA，但它在激活过程中被诱导，并在T辅助型1 （T(H)1）上保持表达，而不是T(H)2细胞。BTLA与抗原受体交联可诱导其酪氨酸磷酸化，并与含有Src同源结构域2 （SH2）的蛋白酪氨酸磷酸酶SHP-1和SHP-2结合，并减少白细胞介素2 （IL-2）的产生。btla缺陷T细胞增殖增加，btla缺陷小鼠特异性抗体反应增加，对实验性自身免疫性脑脊髓炎的敏感性增强。B7x是B7的外周同源物，是BTLA的配体。因此，BTLA是T淋巴细胞上的第三种抑制受体，与细胞毒性T淋巴细胞相关抗原4 （CTLA-4）和程序性死亡1 （PD-1）相似。
During activation, T cells express receptors for receiving positive and negative costimulatory signals. Here we identify the B and T lymphocyte attenuator (BTLA), an immunoglobulin domain-containing glycoprotein with two immunoreceptor tyrosine-based inhibitory motifs. BTLA is not expressed by naive T cells, but it is induced during activation and remains expressed on T helper type 1 (T(H)1) but not T(H)2 cells. Crosslinking BTLA with antigen receptors induces its tyrosine phosphorylation and association with the Src homology domain 2 (SH2)-containing protein tyrosine phosphatases SHP-1 and SHP-2, and attenuates production of interleukin 2 (IL-2). BTLA-deficient T cells show increased proliferation, and BTLA-deficient mice have increased specific antibody responses and enhanced sensitivity to experimental autoimmune encephalomyelitis. B7x, a peripheral homolog of B7, is a ligand of BTLA. Thus, BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1).