Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats
Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats
复制标题
慢性磷脂酰丝氨酸治疗可改善老年大鼠的空间记忆和被动回避
作者：
A. Zanotti;L. Valzelli;G. Toffano
衰老动物中的学习/记忆缺陷被广泛用作评估用于治疗年龄相关认知功能障碍的药剂的治疗潜力的工具。如在Morris水迷宫测试中所评估的，老龄（21-24个月）大鼠显示出空间记忆的可变损失。老年非受损大鼠以及年轻的主题，而老年受损大鼠表现出严重和持续的地方导航，赤字。被动回避保持同样受到影响的两个老年亚群。发现长期口服磷脂酰丝氨酸（50 mg/kg/天，持续12周）（一种抗衰老活性磷脂）可改善老年受损大鼠的空间记忆和被动回避保持。结果进行了讨论与参考磷脂酰丝氨酸诱导的改善与年龄相关的脑功能的恶化。
Learning/memory deficits in senescent animals are widely used as a tool to evaluate the therapeutic potential of agents for treatment of age-associated cognitive dysfunction. As assessed in the Morris water maze test, aged (21–24 months) rats showed a variable loss of spatial memory. Aged non-impaired rats performed as well as young subjects, while aged impaired rats exhibited a severe and persistent place-navigation, deficit. Passive avoidance retention was similarly affected in the two aged subpopulations. Chronic oral administration of phosphatidylserine (50 mg/kg/day for up to 12 weeks), a pharmacologically active phospholipid, was found to improve both the spatial memory and the passive avoidance retention of aged impaired rats. Results are discussed with reference to the phosphatidylserine-induced improvement of age-associated deterioration of brain functions in rats.
老年老鼠的遗忘速度很快。
DOI：
10.1016/s0163-1047(82)90234-5
发表时间：
1982
期刊：
Behavioral and neural biology
影响因子：
--
作者：
Zornetzer,SF;Thompson,R;Rogers,J
通讯作者：
Rogers,J
影响因子：
1.9
作者：
Rapp,PR;Rosenberg,RA;Gallagher,M
通讯作者：
Gallagher,M