COVID-19 in People With Schizophrenia: Potential Mechanisms Linking Schizophrenia to Poor Prognosis.
COVID-19 in People With Schizophrenia: Potential Mechanisms Linking Schizophrenia to Poor Prognosis.
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DOI：
10.3389/fpsyt.2021.666067
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发表时间：
2021
影响因子：
4.7
通讯作者：
Singh SP
中科院分区：
文献类型：
--
作者：
Mohan M;Perry BI;Saravanan P;Singh SP
随着COVID-19造成的全球死亡率负担持续上升，了解谁最有可能出现不良后果至关重要。既存心脏代谢、肾脏和呼吸系统疾病以及年老是与COVID-19患者疾病严重程度和死亡率相关的公认风险因素。然而，越来越多的证据也表明，精神分裂症患者对COVID-19的易感性和不良后果的风险增加，与年龄和合并症无关。因此，阐明可能增加精神分裂症患者不良结局风险的潜在病理生理机制至关重要。在这里，我们提供了一个关于精神分裂症患者对COVID-19的当前理解的叙述，并提出了可能将精神分裂症与COVID-19的易感性增加和不良后果风险增加联系起来的潜在机制。鉴于现有的知识差距，需要进行强有力的临床和生物学研究，以进一步了解其中一些潜在机制，从而制定有效的预防和治疗精神分裂症患者的COVID-19的策略。
As the global burden of mortality from COVID-19 continues to rise, an understanding of who is most at risk of adverse outcomes is of paramount importance. Pre-existing cardiometabolic, renal and respiratory diseases as well as old age are well-established risk factors associated with disease severity and mortality among patients with COVID-19. However, mounting evidence also indicates an increased susceptibility to, and risk of adverse outcomes from COVID-19 in people with schizophrenia, independent of age and comorbidity. Therefore, elucidating the underlying pathophysiological mechanisms which may increase the risk of poor outcomes in people with schizophrenia is of crucial importance. Here, we provide a narrative on the current understanding of COVID-19 in patients with schizophrenia and propose potential mechanisms which may link schizophrenia with an increased susceptibility to, and greater risk of adverse outcomes from COVID-19. Given the existing knowledge gaps, robust clinical and biological studies are required to further our understanding of some of these underlying mechanisms, so that effective prevention and treatment strategies for COVID-19 in patients with schizophrenia can be developed.
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