GLUCOCORTICOID AND THYROID-HORMONES TRANSCRIPTIONALLY REGULATE GROWTH-HORMONE GENE-EXPRESSION
GLUCOCORTICOID AND THYROID-HORMONES TRANSCRIPTIONALLY REGULATE GROWTH-HORMONE GENE-EXPRESSION
复制标题
DOI：
10.1073/pnas.79.24.7659
复制
发表时间：
1982-01-01
期刊：
影响因子：
--
通讯作者：
ROSENFELD, MG
中科院分区：
文献类型：
--
作者：
EVANS, RM;BIRNBERG, NC;ROSENFELD, MG
为了确定糖皮质激素和甲状腺激素调节生长激素基因表达的分子机制，在体内和垂体细胞系[大鼠G/C细胞]中检查了它们对生长激素生物合成发挥作用的部位。糖皮质激素快速增加生长激素mRNA和核RNA前体的积累。糖皮质激素和甲状腺激素快速和独立地增加生长激素基因转录。这些事件发生在动物的生理和进一步建立生长激素基因表达的重要性作为类固醇调节的模型。
To define the molecular mechanisms by which glucocorticoids and thyroid hormone act to regulate growth hormone gene expression, the sites at which they exert their effects on growth hormone biosynthesis were examined in vivo and in a pituitary cell line [rat G/C cells]. Glucocorticoids rapidly increase accumulation of growth hormone mRNA and nuclear RNA precursors. Glucocorticoids and thyroid hormone rapidly and independently increase growth hormone gene transcription. These events occur physiologically in animals and further establish the importance of growth hormone gene expression as a model for steroid regulation.