Eyes absent homologue 2 predicts a favorable prognosis in colorectal cancer.
Eyes absent homologue 2 predicts a favorable prognosis in colorectal cancer.
复制标题
眼睛缺失同源物2预示着结直肠癌的良好预后
DOI：
10.2147/ott.s164149
复制
发表时间：
2018
影响因子：
4
通讯作者：
Guo A
中科院分区：
文献类型：
--
作者：
Zheng J;Cao F;Huang X;Ramen K;Xu X;Zhu Y;Chang W;Shan Y;Guo A
眼缺失同源物2（EYA 2）作为转录激活因子和磷酸酶发挥作用，在几种类型的癌症中起重要作用。然而，EYA 2在结直肠癌（CRC）中的影响仍然难以捉摸。我们评估了EYA 2表达在包括922例结直肠癌病例的大型队列中的结直肠癌发生和进展中的意义。免疫组化法检测大肠组织中EYA 2蛋白的表达。研究大肠癌组织及癌旁正常组织中EYA 2的表达与大肠癌发生的关系。采用Kaplan-Meier和考克斯模型分析影响结直肠癌预后的因素。EYA 2在癌旁正常组织、腺瘤、原发癌和转移癌中的表达逐渐降低（P均<0.05）。EYA 2的表达与疾病分期、分化程度、淋巴结切除数有关（P均<0.001）。在多变量考克斯分析中，在调整混杂因素如肿瘤淋巴结转移分期和分级后，与EYA 2高肿瘤患者相比，EYA 2低肿瘤患者的无病生存期（风险比[HR]，2.347; 95% CI，1.665-3.308）和疾病特异性生存期（HR，3.560; 95% CI，2.055-6.167）较短。特别是，II期或III期EYA 2-低CRC患者可能会受到术后化疗的伤害。EYA 2表达在CRC中普遍降低。EYA 2高表达可预测结直肠癌预后更好。
Eyes absent homologue 2 (EYA2), which functions as a transcription activator and phosphatase, plays an important role in several types of cancer. However, the impact of EYA2 in colorectal cancer (CRC) remains elusive. We evaluated the significance of EYA2 expression in the development and progression of CRC in a large cohort, including 922 CRC cases. EYA2 protein expression was determined via immunohistochemistry in colorectal tissues. The correlation between EYA2 expression and CRC occurrence was investigated in tumor tissue and the adjacent normal tissues. Factors contributing to CRC prognosis were evaluated using Kaplan–Meier and Cox model analyses. EYA2 expression was progressively lower in the adjacent normal tissue, adenomas, primary tumor and the metastatic CRC (all P<0.05). Furthermore, EYA2 expression had significant associations with disease stage, differentiation grade, and number of resected lymph nodes (all P<0.001). Compared with patients with EYA2-high tumors, those with EYA2-low tumors had shorter disease-free survival (hazard ratio [HR], 2.347; 95% CI, 1.665–3.308) and disease-specific survival (HR, 3.560; 95% CI, 2.055–6.167) in multivariate Cox analysis, after adjusting confounding factors such as tumor-node-metastasis stage and grade. In particular, patients with stage II or III EYA2-low CRC might be harmed by postoperative chemotherapy. EYA2 expression was generally reduced in CRC. Higher EYA2 expression can predict a more favorable prognosis for CRC.