Adipose concentrations of organochlorine compounds and breast cancer recurrence in Long Island, New York.
Adipose concentrations of organochlorine compounds and breast cancer recurrence in Long Island, New York.
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DOI：
10.7916/d8m61hwx
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发表时间：
2003-12
期刊：
影响因子：
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通讯作者：
J. Muscat;J. Britton;M. Djordjevic;M. Citron;M. Kemeny;E. Busch-Devereaux;B. Pittman;S. Stellman-S.-Stell
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文献类型：
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作者：
J. Muscat;J. Britton;M. Djordjevic;M. Citron;M. Kemeny;E. Busch-Devereaux;B. Pittman;S. Stellman-S.-Stell
一些研究测量了血液或脂肪中有机氯化合物（OC）浓度（如农药和多氯联苯）与乳腺癌之间的关系。OC的雌激素样作用可能对乳腺癌复发产生不利影响。参与者是224名非转移性乳腺癌妇女，参加了一项基于纽约的病例对照研究。超临界流体萃取，然后气相色谱法进行脂肪手术标本，以确定OC浓度。手术后平均随访时间为3.6年。30名妇女（13.4%）被诊断为复发。农药和多氯联苯的浓度与基线年龄和体重指数相关，但与癌症分期无关。PCB总浓度的最高三分位数与复发风险增加相关[相对风险（RR），2.9; 95%置信区间（CI），1.02-8.2与最低三分位数相比]。多氯联苯同系物Ballschmiter和策尔118的最高三分位数风险为4.0（95% CI，1.3-4.9）。含量最高的农药1，1-二氯-2，2-二（4-氯苯基）乙烯（RR，2.3; 95% CI，0.9-5.7）和乙型六氯环己烷的中等水平风险增加，但其最高水平风险不增加。自我报告的家庭杀白蚁剂暴露、饮酒（>或= 1杯/天）和种族与预后无关。诊断时吸烟的RR为2.1（95% CI，0.9-5.1）。以前的数据显示，OC暴露和乳腺癌的风险之间没有关系，在这些妇女，脂肪PCB浓度与肿瘤复发。农药水平与复发无关。
Several studies have measured the association between blood or adipose concentrations of organochlorinated compounds (OCs), such as pesticides and polychlorinated biphenyls (PCBs), and breast cancer. The estrogenic effects of OCs might adversely affect breast cancer recurrence. The participants were 224 women with nonmetastatic breast cancer enrolled in a New York-based case-control study. Supercritical fluid extraction followed by gas chromatography was conducted on adipose surgical specimens to determine OC concentrations. The mean follow-up time from surgery was 3.6 years. Thirty women (13.4%) were diagnosed with a recurrence. The concentration of pesticides and PCBs was correlated with baseline age and body mass index, but not with cancer stage. The highest tertile of total PCB concentration was associated with an increased risk of recurrence [relative risk (RR), 2.9; 95% confidence interval (CI), 1.02-8.2 versus the lowest tertile]. The risk for the highest tertile of the PCB congener Ballschmiter and Zell 118 was 4.0 (95% CI, 1.3-4.9). There was an increased risk for the middle level of the most abundant pesticide, 1,1-dichloro-2,2-di(4-chlorophenyl)ethylene (RR, 2.3; 95% CI, 0.9-5.7), and for beta-hexachlorocyclohexane, but not for their highest levels. Self-reported home termiticide exposure, alcohol consumption (> or = 1 drink/day), and race were not associated with prognosis. The RR for current cigarette smoking at diagnosis was 2.1 (95% CI, 0.9-5.1). In contrast to previous data showing no relationship between OC exposure and risk of breast cancer in these women, adipose PCB concentrations were associated with tumor recurrence. Pesticide levels were not related to recurrence.