Detection of Candida dubliniensis in Venezuela
Detection of Candida dubliniensis in Venezuela
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DOI：
10.1007/s11046-005-6873-y
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发表时间：
2005-10-01
期刊：
影响因子：
5.5
通讯作者：
Abate, SMT
中科院分区：
文献类型：
--
作者：
de Capriles, CH;Mata-Essayag, S;Abate, SMT
在过去的几十年中，念珠菌属引起的真菌感染显著增加，并且在感染人类免疫缺陷病毒（HIV）的免疫功能低下个体中仍然很常见。虽然白色念珠菌仍然是最常见的口腔机会致病菌，但在这组患者中也经常发现其他非白色念珠菌，包括念珠菌。都柏林的。该酵母与C.白色念珠菌这两个物种的菌落在不生长在特殊培养基上时，在形态上是相同的。结果表明，C. Dubliniensis和C. albicans提示许多C. dubliniensis分离物可能被误鉴定为C.白色的过去本研究的目的是恢复和鉴定C。dubliniensis和推定的临床C.白念珠菌，从口腔的艾滋病毒血清阳性的个人，比较传统的媒体，以获得一个简单的，低成本和可靠的鉴定系统。都柏林的。从402例HIV感染者中分离到16株（3.98%）经鉴定为C.都柏林的。在这些C之外。19%的dubliniensis菌株对氟康唑耐药，MIC高于64 μ g/ml。据提交人所知，这是在委内瑞拉首次发现这种生物。
Over the past decades there has been a significant increase in fungal infections caused by Candida species, and continues to be common in immunocompromised individuals infected with the human immunodeficiency virus (HIV). Although Candida albicans remains the fungal species most frequently isolated as an opportunistic oral pathogen, other non-albicans ate often identified in this cohort of patients, including C. dubliniensis. This yeast is closely related to and shares many phenotypic characteristics with C. albicans. Colonies of these two species appear morphologically identical when not grown on special media. The shared phenotypic characteristics of C. dubliniensis and C. albicans suggest that many C. dubliniensis isolates may have been misidentified as C. albicans in the past. The present studies aim is to recover and identify C. dubliniensis, and presumptive clinical C. albicans, from the oral cavities of HIV-seropositive individuals, comparing conventional media to obtain a simple, low-cost and reliable identification system for C. dubliniensis. A total of 16 isolates (3,98%) had been obtained from 402 HIV infected individuals with recurrent oropharyngitis and were identified as C. dubliniensis. Out of these C. dubliniensis isolates 19% were resistant, with MICs above 64 mu g/ml to fluconazole. This constitutes, to the authors knowledge the first recovery of this organism in Venezuela.