Association of telomere length and mitochondrial DNA copy number with risperidone treatment response in first-episode antipsychotic-naïve schizophrenia.
Association of telomere length and mitochondrial DNA copy number with risperidone treatment response in first-episode antipsychotic-naïve schizophrenia.
复制标题
首发抗精神病药物治疗精神分裂症中端粒长度和线粒体 DNA 拷贝数与利培酮治疗反应的关系
DOI：
10.1038/srep18553
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发表时间：
2015-12-18
影响因子：
4.6
通讯作者：
Tang J
中科院分区：
文献类型：
--
作者：
Li Z;Hu M;Zong X;He Y;Wang D;Dai L;Dong M;Zhou J;Cao H;Lv L;Chen X;Tang J
越来越多的证据表明，端粒长度和线粒体功能与精神分裂症（SCZ）的抗精神病药物反应之间存在假定的关联。然而，药理学结果是有限的，没有以前的工作进行了评估，在一个前瞻性的纵向研究。本研究评估了利培酮治疗8周的首次发作抗精神病药物初治SCZ患者的端粒长度和线粒体DNA拷贝数，以评价这些生物标志物与临床治疗应答之间的相关性。我们招募了137名首次发作抗精神病药物初治的SCZ患者（和144名对照），其中89名患者完成了8周的随访。完成随访的患者根据症状改善的百分比分为应答者（N = 46）和非应答者（N = 43）。线性回归分析显示，与健康对照组相比，SCZ患者的mtDNA拷贝数显著降低（β =-0.108，p = 0.002），端粒长度没有改变。此外，与无应答者相比，在8周治疗前，应答者的mtDNA拷贝数显著较低（β =-0.178，p = 0.001），端粒长度较长（β = 0.111，p = 0.071）。治疗后，与无应答者相比，应答者的mtDNA拷贝数持续较低（部分η2 = 0.125，p = 0.001）。这些结果表明，端粒长度和mtDNA拷贝数可能持有作为SCZ患者的抗精神病药物反应的预测。
Accumulating evidence indicates a putative association of telomere length and mitochondrial function with antipsychotics response in schizophrenia (SCZ). However, pharmacological findings were limited and no previous work has assessed this in a prospective longitudinal study. This study assessed telomere length and mitochondrial DNA copy number in first-episode antipsychotic-naïve SCZ patients with 8-week risperidone treatment to evaluate the association between these biomarkers and clinical treatment response. We recruited 137 first-episode antipsychotic-naive SCZ patients (and 144 controls) at baseline and 89 patients completed the 8-week follow-up. Patients, completed follow-up, were divided into Responders (N = 46) and Non-Responders (N = 43) according to the percentage of symptoms improvement. Linear regression analyses show that SCZ patients had significantly lower mtDNA copy number (β = −0.108, p = 0.002), and no alteration of telomere length when compared with healthy controls. In addition, compared with Non-Responders, Responders had significantly lower mtDNA copy number (β = −0.178, p = 0.001), and longer telomere length (β = 0.111, p = 0.071) before the 8-week treatment. After treatment, Responders persisted lower mtDNA copy number comparing with No-Responders (partial η2 = 0.125, p = 0.001). These findings suggest that telomere length and mtDNA copy number may hold the potential to serve as predictors of antipsychotic response of SCZ patients.