LUTEOLIN AND THIOSALICYLATE INHIBIT HgCl2 AND THIMEROSAL-INDUCED VEGF RELEASE FROM HUMAN MAST CELLS
LUTEOLIN AND THIOSALICYLATE INHIBIT HgCl2 AND THIMEROSAL-INDUCED VEGF RELEASE FROM HUMAN MAST CELLS
复制标题
DOI：
10.1177/039463201002300406
复制
发表时间：
2010-10-01
影响因子：
3.5
通讯作者：
Theoharides, T. C.
中科院分区：
文献类型：
--
作者：
Asadi, S.;Zhang, B.;Theoharides, T. C.
氯化汞是一种已知的环境神经毒素，但也用作疫苗中的防腐剂，如硫柳汞，含有与硫代水杨酸盐共价连接的乙基汞。我们最近报道，氯化汞（HgCl 2）可以刺激人肥大细胞释放血管内皮生长因子（VEGF），这也是血管活性和促炎。在此，我们发现，与对照细胞（242 +/- 21 pg/10（6）细胞，n=5，p < 0.05）相比，硫柳汞诱导人白血病培养的LAD 2肥大细胞（1 μ M时为326 +/-12 pg/10（6）细胞，10 μ M时为335.5 +/- 12 pg/10（6）细胞）显著释放VEGF。
HgCl2 is a known environmental neurotoxin, but is also used as preservative in vaccines as thimerosal containing ethyl mercury covalently linked to thiosalicylate. We recently reported that mercury chloride (HgCl2) can stimulate human mast cells to release vascular endothelial growth factor (VEGF), which is also vasoactive and pro-inflammatory. Here we show that thimerosal induces significant VEGF release from human leukemic cultured LAD2 mast cells (at 1 mu M 326 +/- 12 pg/10(6) cells and 335.5 +/- 12 pg/10(6) cells at 10 mu M) compared to control cells (242 +/- 21 pg/10(6) cells, n=5, p