Macular microholes
Macular microholes
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DOI：
10.1097/01.iae.0000243068.68099.b4
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发表时间：
2007-06-01
影响因子：
3.3
通讯作者：
Klein, Michael L.
中科院分区：
文献类型：
--
作者：
Emerson, Geoffrey G.;Spencer, Gregory R.;Klein, Michael L.
目的：描述黄斑微孔的临床特点和自然病程。方法：回顾31例(35眼)黄斑中心凹点状缺损者的临床资料。患者在1980年至2005年期间在一家第三转诊中心就诊。复习临床、摄影和光学相干断层扫描的结果。结果：所有的眼睛都有一个或多个清晰的、点状的黄斑中心凹病变，大小在35am到150am。没有性别偏好，患者年龄从6岁到69岁不等。在35只眼中，29只眼的视力为20/40。荧光素眼底血管造影术均未发现黄斑中心凹传输缺陷。在接受光学相干断层扫描的7名患者中，有5名患者的外层视网膜出现了缺陷。结论：黄斑微孔是一种位于视网膜外层或视网膜色素上皮的小板层缺陷，其发生机制多种多样，包括自发性玻璃体-视网膜界面改变、创伤、光毒性及其他不明原因。这种情况是非进行性的，发生在所有年龄段的患者中，并且与良好的视力相适应。
Purpose: To describe the clinical features and natural course of microholes of the macula.Methods: We reviewed the charts of 31 patients (35 eyes) with punctate foveal defects, or "microholes," of the macula. Patients were seen between 1980 and 2005 at a tertiary referral center. Clinical, photographic, and optical coherence tomography findings were reviewed.Results: All eyes had one or more well defined, punctate foveal lesions 35 Am to 150 Am in size. There was no gender predilection, and patient ages ranged from 6 years to 69 years. Visual acuity was >= 20/40 in 29 of 35 eyes. None of the eyes had foveal transmission defects shown by fluorescein angiography. A defect in the outer retina was demonstrated in five of seven patients who underwent optical coherence tomography. The lesions were nonprogressive, with no patients developing stage 3 or 4 macular holes.Conclusion: Macular microholes are small lamellar defects in the outer retina or retinal pigment epithelium that occur through a variety of mechanisms, including spontaneous vitreoretinal interface changes, trauma, phototoxicity, and other unrecognized causes. The condition is nonprogressive, occurs in patients of all ages, and is compatible with good visual acuity.