Transcranial magnetic stimulation as an investigative tool for motor dysfunction and recovery in stroke: an overview for neurorehabilitation clinicians.
Transcranial magnetic stimulation as an investigative tool for motor dysfunction and recovery in stroke: an overview for neurorehabilitation clinicians.
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DOI：
10.1111/j.1525-1403.2012.00459.x
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发表时间：
2012-07
期刊：
影响因子：
--
通讯作者：
Edwards DJ
中科院分区：
文献类型：
--
作者：
Cortes M;Black-Schaffer RM;Edwards DJ
更好地了解中风后运动功能障碍和恢复具有重要的临床意义，可能有助于为偏瘫患者设计更有效的康复策略。经颅磁刺激 (TMS) 是一种安全、无痛的工具，已与其他现有诊断工具结合使用来研究中风患者的运动病理生理学。自二十多年前 TMS 出现以来，其在临床和基础神经科学中的应用已在全球范围内扩展。 TMS 可以量化临床受影响和未受影响肌肉的皮质运动兴奋性特性，并探测局部皮质网络以及远程但功能相关的区域。这为运动功能障碍背后的神经回路的生理学以及运动恢复过程中的大脑重组提供了新的见解。临床研究人员需要谨慎使用这一重要工具，需要了解其局限性，并且应结合该患者群体的临床评估来解释结果。在这篇综述中，我们概述了 TMS 研究中风运动生理学的基本原理、实施和局限性。这些知识可能有助于通过评估和促进功能可塑性来指导未来的康复治疗。
An improved understanding of motor dysfunction and recovery after stroke has important clinical implications that may lead to the design of more effective rehabilitation strategies for patients with hemiparesis. Transcranial magnetic stimulation (TMS) is a safe and painless tool that has been used in conjunction with other existing diagnostic tools to investigate motor pathophysiology in stroke patients. Since TMS emerged over two decades ago, its application in clinical and basic neuroscience has expanded worldwide. TMS can quantify the corticomotor excitability properties of clinically affected and unaffected muscles, and probe local cortical networks, as well as remote but functionally related areas. This provides novel insight into the physiology of neural circuits underlying motor dysfunction, and brain reorganization during the motor recovery process. This important tool needs to be used with caution by clinical investigators, its limitations need to be understood and the results should be interpreted along with clinical evaluation in this patient population. In this review, we provide an overview of the rationale, implementation and limitations of TMS to study stroke motor physiology. This knowledge may be useful to guide future rehabilitation treatments by assessing and promoting functional plasticity.
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影响因子：
16.2
作者：
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DOI：
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DOI：
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影响因子：
4.3
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