Body mass index, physical activity, and risk of renal cell carcinoma
Body mass index, physical activity, and risk of renal cell carcinoma
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DOI：
10.1038/sj.ijo.0803231
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发表时间：
2006-06-01
影响因子：
4.9
通讯作者：
Cantor, KP
中科院分区：
文献类型：
--
作者：
Chiu, BCH;Gapstur, SM;Cantor, KP
目的：调查肥胖与肾细胞癌风险之间的关联，并检验这种关联是否会因体力活动而改变。 受试者：在爱荷华州进行的一项基于人群的病例对照研究，纳入了 406 名肾细胞癌患者和 2434 名对照组。方法：收集了 20-29 岁、40-49 岁和 60-69 岁的体重、身高、非职业体力活动、饮食和其他生活方式因素的信息。肾细胞癌风险通过比值比 (OR) 和 95% 置信区间 (CI) 进行评估，并调整年龄、总能量摄入量和其他混杂因素。结果：身高和总能量摄入量与任何性别的风险均无关。对于男性来说，生命任何时期的体力活动和肥胖程度均与风险无关。在女性中，较低的体力活动与较高的风险相关（OR 2.5；95% CI 1.2-5.2，比较运动<1次/月与>1次/天）。与BMI最低四分位数的女性相比，20多岁、40多岁和60多岁BMI最高10%的女性患肾细胞癌的风险分别为1.4（CI = 0.6-3.1）、1.9（CI = 0.9-4.2）和2.3（CI = 0.9-6.0）。当分析仅限于自答数据时，相应的 OR 分别为 2.9 (CI = 1.2-7.4)、3.2 (CI = 1.3-7.5) 和 2.1 (CI = 0.7-6.4)。几乎没有证据表明体力活动会改变 BMI 与肾细胞癌的关联。结论：非职业体力活动与女性肾细胞癌风险呈负相关，肥胖与肾细胞癌风险呈正相关。对于 40 多岁体重指数最高 10% 的女性来说，这种风险似乎更大。我们发现几乎没有证据表明体力活动与体重指数之间存在相互作用，这需要证实。
Objective: To investigate the association between obesity and risk of renal cell carcinoma and to examine whether the association is modified by physical activity.Subjects: A population-based case-control study of 406 patients with renal cell carcinoma and 2434 controls conducted in Iowa.Methods: Information was collected on weight at the ages 20-29, 40-49, and 60-69 years, height, nonoccupational physical activity, diet, and other lifestyle factors. Renal cell carcinoma risk was estimated by odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for age, total energy intake, and other confounding factors.Results: Height and total energy intake were not associated with risk in either sex. In men, neither physical activity nor level of obesity in any period of life was significantly associated with risk. In women, lower physical activity was associated with higher risk (OR 2.5; 95% CI 1.2-5.2 comparing exercise < 1 time/month to > 1 time/day). Compared with women in the lowest quartile for BMI, the risks of renal cell carcinoma for women in the highest 10% of BMI in their 20s, 40s, and 60s were 1.4 (CI = 0.6-3.1), 1.9 (CI = 0.9-4.2), and 2.3 (CI = 0.9-6.0), respectively. When analyses were limited to self-respondent data, the corresponding ORs were 2.9 (CI = 1.2-7.4), 3.2 (CI = 1.3-7.5), and 2.1 (CI = 0.7-6.4), respectively. There was little evidence that physical activity modifies the association of BMI with renal cell carcinoma.Conclusion: Nonoccupational physical activity was inversely associated and obesity was positively associated with risk of renal cell carcinoma among women. The risk appeared to be greater for women in the highest 10% of BMI in their 40s. Our finding of little evidence of an interaction between physical activity and BMI requires confirmation.