Development of a human live attenuated West Nile infectious DNA vaccine: conceptual design of the vaccine candidate.
Development of a human live attenuated West Nile infectious DNA vaccine: conceptual design of the vaccine candidate.
复制标题
人类减毒西尼罗河传染性 DNA 疫苗的开发：候选疫苗的概念设计。
DOI：
10.1016/j.virol.2015.04.027
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Yamshchikov,Vladimir
中科院分区：
文献类型：
--
作者：
Yamshchikov,Vladimir
西尼罗河病毒已经成为一个重要的流行病学问题，引起了卫生当局、大众媒体和公众的高度关注。尽管在解决疫苗需求方面取得了有希望的进展，但疫苗的商业可获得性的前景仍然不确定。在很大程度上，这是由于对已经在进行临床前和临床开发的疫苗的进一步商业开发缺乏持续的兴趣，以及预计大规模疫苗接种的成本效益不大。需要一种安全、有效和成本效益高的疫苗，以提高有针对性的疫苗接种计划的可行性。在本报告中，我们总结了我们为设计一种新的感染性DNA格式的西尼罗河减毒活疫苗而选择的开发路线的背景、原理和选择。
West Nile virus has become an important epidemiological problem attracting significant attention of health authorities, mass media, and the public. Although there are promising advancements toward addressing the vaccine need, the perspectives of the commercial availability of the vaccine remain uncertain. To a large extent this is due to lack of a sustained interest for further commercial development of the vaccines already undergoing the preclinical and clinical development, and a predicted insignificant cost effectiveness of mass vaccination. There is a need for a safe, efficacious and cost effective vaccine, which can improve the feasibility of a targeted vaccination program. In the present report, we summarize the background, the rationale, and the choice of the development pathway that we selected for the design of a live attenuated human West Nile vaccine in a novel infectious DNA format.