Enantioconvergent alkylation of ketones with racemic secondary alcohols via hydrogen borrowing catalysis
Enantioconvergent alkylation of ketones with racemic secondary alcohols via hydrogen borrowing catalysis
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DOI：
10.1039/d0cc00767f
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发表时间：
2020-03-25
影响因子：
4.9
通讯作者：
Donohoe, Timothy J.
中科院分区：
文献类型：
--
作者：
Cheang, Daniella M. J.;Armstrong, Roly J.;Donohoe, Timothy J.
本文报道了邻二取代芳基酮与外消旋仲醇的烷基化反应。该过程由市售铱催化剂介导，并通过氢借用催化进行。高度对映体富集的β-取代的酮产物容易通过逆傅-克酰化裂解成宽范围的官能团。
An enantioconvergent method for the alkylation of o-disubstituted aryl ketones with racemic secondary alcohols is described. This process is mediated by a commercially available iridium catalyst and proceeds via hydrogen borrowing catalysis. The highly enantioenriched beta-substituted ketone products were readily cleaved to a wide range of functional groups via retro-Friedel-Crafts acylation.