Integrins: A flexible platform for endothelial vascular tyrosine kinase receptors
Integrins: A flexible platform for endothelial vascular tyrosine kinase receptors
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DOI：
10.1016/j.autrev.2007.03.007
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发表时间：
2007-11-01
影响因子：
13.6
通讯作者：
Bussolino, Federico
中科院分区：
文献类型：
--
作者：
Napione, Lucia;Cascone, Ilaria;Bussolino, Federico
与低等后生动物相比，脊椎动物在组织发育及其功能中建立了一套全新的与粘附相关的基因。它们包括多种细胞外基质蛋白及其异二聚体整合素粘附受体。整合素通过复杂的分子机制控制细胞的粘附状态。由外向内的信号传递告知细胞外基质环境，而由内向外的信号传递导致整合素功能活性的变化。在过去的10年里，它已经很好地建立了来自整合素和可溶性生长因子受体的信号的相互整合。本文综述了目前对血管内皮细胞中这种联系的理解，并强调了整合素在胚胎发育和成人生活中如何调节由血管生成诱导剂触发的遗传程序。(c) 2007 Elsevier B.V.版权所有
Compared to lower metazoans, vertebrates built up an exclusively new set of adhesion-related genes involved in the tissue development and in their functions. They include a large variety of extracellular matrix proteins and their heterodimeric integrin adhesive receptors. Integrins control the adhesive state of the cell through complex molecular mechanisms. Outside-in signalling informs the cell about the extracellular matrix environment, while Inside-out signalling results in changes in integrin functional activity. In the last 10 years it has well established a reciprocal integration of signals originating from integrins and receptors for soluble growth factors. This review summarizes the current understanding of this connection in vascular endothelial cells and highlights how integrins regulate a genetic program triggered by angiogenic inducers during embryo development and in adult life. (c) 2007 Elsevier B.V. All rights reserved.