Persistent osteopenia in adolescent idiopathic scoliosis - A longitudinal follow-up study
Persistent osteopenia in adolescent idiopathic scoliosis - A longitudinal follow-up study
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DOI：
10.1097/00007632-199906150-00008
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发表时间：
1999-06-15
期刊：
影响因子：
3
通讯作者：
Sher, AHL
中科院分区：
文献类型：
--
作者：
Cheng, JCY;Guo, X;Sher, AHL
研究设计.一项评估青少年特发性脊柱侧凸患者骨矿物质动力学的随访研究。探讨青少年特发性脊柱侧凸患者的骨量减少是一种暂时现象还是一种持续性问题。研究者认为骨量减少与青少年特发性脊柱侧凸有显著相关性。由于一半的骨骼质量是在青少年时期获得的，因此了解骨量减少是暂时的还是持续的是很重要的。采用双能X线骨密度仪，对70例正常对照组和14例骨量减少超过正常值2个标准差的青少年特发性脊柱侧凸患者的双侧股骨近端骨密度进行纵向研究。14例骨质疏松性青少年特发性脊柱侧凸女孩与正常年龄、性别和成熟度匹配的对照组相比，纵向随访长达3年，骨密度持续显著降低。青少年特发性脊柱侧凸患者比健康青少年患骨质疏松症的风险更高。低骨密度的青少年特发性脊柱侧凸患者的骨密度增加率较低，这可能预示着成年后峰值骨量明显较低，并伴有骨质疏松症的所有相关问题。需要进一步的研究来确定骨质减少相关性脊柱侧凸与青少年脊柱侧凸相比是否具有相同的病因、发病机制和进展风险。
Study Design. A follow-up study assessing the bone mineral dynamics in adolescent patients with idiopathic scoliosis and associated osteopenia.Objectives. To investigate whether osteopenia in patients with adolescent idiopathic scoliosis is a transient phenomenon or a persistent problem.Summary of Background Data. Investigators have suggested a significant correlation of osteopenia with adolescent idiopathic scoliosis. Because one half of the skeletal mass is acquired during the adolescent years, it is of importance to know whether the osteopenia is transient or persistent.Methods. Using dual-energy x-ray absorptiometry, bone mineral density of bilateral proximal femurs was studied longitudinally in 70 healthy control subjects and 14 patients with adolescent idiopathic scoliosis with significant osteopenia more than 2 standard deviations below the mean normal value.Results. The 14 girls with osteopenic adolescent idiopathic scoliosis who were followed up longitudinally for up to 3 years showed persistent and significantly lower bone mineral density when compared with normal age-, sex- and maturity-matched control subjects.Conclusions. Patients with adolescent idiopathic scoliosis are at increased risk of osteoporosis than are healthy adolescents. The lower rate of increase of bone mineral density in patients with adolescent idiopathic scoliosis who have low bone mineral density could predict a significantly lower peak bone mass in adulthood, with all the associated problems of osteoporosis. Further investigation is needed to define whether osteopenia-associated scoliosis has the same cause, pathogenetic mechanism, and risk of progression when compared with adolescent scoliosis without osteopenia.