Biological differences in endogenous depressive placebo responders versus nonresponders: dexamethasone suppression test and sleep EEG data.
Biological differences in endogenous depressive placebo responders versus nonresponders: dexamethasone suppression test and sleep EEG data.
复制标题
内源性抑郁安慰剂反应者与无反应者的生物学差异：地塞米松抑制试验和睡眠脑电图数据。
DOI：
10.1016/0006-3223(88)90128-x
复制
发表时间：
1988
影响因子：
10.6
通讯作者：
Roth,T
中科院分区：
文献类型：
--
作者：
Zammit,GK;Rosenbaum,AH;Stokes,P;Davis,J;Zorick,F;Roth,T
异常地塞米松抑制试验 (DST) 和睡眠脑电图 (EEG) 结果与抑郁症患者对积极药物治疗的反应之间的关联是模棱两可的。然而，最近，研究人员试图确定这些措施与躯体治疗和非躯体治疗的反应之间的关系。 Carroll (1985) 报告说，DST 非抑制者不太可能对心理治疗和支持产生反应，除非同时给予躯体治疗。同样，Georgotas 及其同事（Carroll 1985 年引用）发现，DST 异常的患者对安慰剂治疗没有反应，而 DST 正常的患者有很高的反应率。一项研究甚至表明夏令时异常
The association between abnormal Dexamethasone Suppression Test (DST) and sleep electroencephalographic (EEG) findings and depressives’ response to active drug treatment is equivocal. Recently, however, investigators have attempted to determine the relationship between these measures and response to somatic versus nonsomatic treatment. Carroll (1985) has reported that DST nonsuppressors are not likely to respond to psychotherapy and support unless somatic treatment is also given. Similarly, Georgotas and associates (cited in Carroll 1985) found that patients with abnormal DSTs did not respond to treatment with placebo, whereas those with normal DSTs had a high rate of response. One study has even shown that abnormal DST