Lipids in host-pathogen interactions: pathogens exploit the complexity of the host cell lipidome.
Lipids in host-pathogen interactions: pathogens exploit the complexity of the host cell lipidome.
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DOI：
10.1016/j.plipres.2009.07.003
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发表时间：
2010-01
影响因子：
13.6
通讯作者：
Helms JB
中科院分区：
文献类型：
--
作者：
van der Meer-Janssen YP;van Galen J;Batenburg JJ;Helms JB
长期以来，人们一直认为脂质在生物膜中具有结构作用，并利用细胞脂滴和血浆脂蛋白储存能量。过去几十年的研究已经确定了脂质在细胞信号传导、膜微域组织和动力学以及膜运输中的额外作用。这些特性使脂质成为病原体调节宿主细胞过程以使其存活和复制的一个有吸引力的目标。在这篇综述中，我们将总结病原体经常巧妙的策略来改变宿主细胞的脂质稳态，使它们能够转移细胞过程。为此目的，病原体充分利用脂质组的复杂性。这些例子被归类为广义的和新兴的原理，描述了脂质在宿主-病原体相互作用中的参与。几种病原体被描述同时诱导宿主细胞信号传导和运输机制的多种变化。阐明这些病原体诱导的变化可能对药物开发具有重要意义。高通量脂质组学技术的出现将允许在单个分子脂质的水平上描述宿主细胞脂质组的变化，并鉴定脂质生物标志物。
Lipids were long believed to have a structural role in biomembranes and a role in energy storage utilizing cellular lipid droplets and plasma lipoproteins. Research over the last decades has identified an additional role of lipids in cellular signaling, membrane microdomain organization and dynamics, and membrane trafficking. These properties make lipids an attractive target for pathogens to modulate host cell processes in order to allow their survival and replication. In this review we will summarize the often ingenious strategies of pathogens to modify the lipid homeostasis of host cells, allowing them to divert cellular processes. To this end pathogens take full advantage of the complexity of the lipidome. The examples are categorized in generalized and emerging principles describing the involvement of lipids in host–pathogen interactions. Several pathogens are described that simultaneously induce multiple changes in the host cell signaling and trafficking mechanisms. Elucidation of these pathogen-induced changes may have important implications for drug development. The emergence of high-throughput lipidomic techniques will allow the description of changes of the host cell lipidome at the level of individual molecular lipid species and the identification of lipid biomarkers.
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影响因子：
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