PELVIC NERVE INNERVATION OF THE EXTERNAL SPHINCTER OF URETHRA AS SUGGESTED BY URODYNAMIC AND HORSERADISH-PEROXIDASE STUDIES
PELVIC NERVE INNERVATION OF THE EXTERNAL SPHINCTER OF URETHRA AS SUGGESTED BY URODYNAMIC AND HORSERADISH-PEROXIDASE STUDIES
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DOI：
10.1016/s0022-5347(17)50511-x
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发表时间：
1984-01-01
影响因子：
6.6
通讯作者：
TSUCHIDA, S
中科院分区：
文献类型：
--
作者：
MORITA, T;NISHIZAWA, O;TSUCHIDA, S
鉴于膀胱逼尿肌和尿道外括约肌在排尿过程中具有密切的协同作用，本实验旨在探讨盆腔传出神经元对尿道外括约肌的作用。通过尿动力学评估和辣根过氧化物酶（HRP）逆行轴突运输技术的组织化学研究，盆腔传出神经元通常被识别为支配膀胱逼尿肌。在15只成年狗的研究中，7外尿道括约肌继续表现出正常的协同肌电图模式，增强电活动的膀胱扩张和放电消失的膀胱收缩，即使在双侧切断阴部神经。只有在随后的双侧盆腔神经切断术后，括约肌中的放电才停止。HRP阳性细胞被证明在中间外侧和中间内侧核和骶髓的Onuf核。apprx。 盆神经注射植物过氧化物酶组1/2。显然，盆神经可能含有支配尿道外括约肌的躯体纤维。
In view of the fact that the detrusor vesicae and external urethral sphincter perform closely synergic functions in micturition, experiments were conducted to explore the action of the pelvic efferent neurons on the external urethral sphincter. The pelvic efferent neurons are generally recognized, by urodynamic assessments and histochemical study with the technique of retrograde axonal transport of horseradish peroxidase [HRP], to innervate the vesical detrusor. In 7 of 15 adult dogs studied, the external urethral sphincter continued to show a normal synergic electromyogram pattern with enhanced electrical activity on vesical distention and disappearance of discharges on vesical contraction even after bilateral transection of the pudendal nerves. The electrical discharges ceased in the sphincter only after subsequent bilateral pelvic neurotomy. HRP-positive cells were demonstrated in the intermediolateral and intermediomedial nuclei and in the Onuf nucleus of the sacral cord in .apprx. 1/2 the dogs whose pelvic nerve was injected with the plant peroxidase. Apparently, the pelvic nerve may contain somatic fibers innervating the external urethral sphincter.