First detection and genome sequencing of SARS-CoV-2 in an infected cat in France
First detection and genome sequencing of SARS-CoV-2 in an infected cat in France
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DOI：
10.1111/tbed.13659
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发表时间：
2020-06-23
影响因子：
4.3
通讯作者：
Le Poder, Sophie
中科院分区：
文献类型：
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作者：
Sailleau, Corinne;Dumarest, Marine;Le Poder, Sophie
在中国武汉首次被发现后，2019冠状病毒病（COVID-19）的病原体SARS-CoV-2迅速在全球传播。之前的研究表明，宠物可能容易感染SARS-CoV-2。在这里，我们调查了22只猫和11只狗的疑似感染情况，这些猫和狗的主人以前感染过或怀疑感染过SARS-CoV-2。对每只动物取直肠、鼻咽拭子和血清。对拭子进行针对SARS-CoV-2 2个基因的RT-qPCR检测。所有狗均检测为SARS-CoV-2阴性。1只猫直肠拭子RT-qPCR检测阳性。该动物的鼻咽拭子检测呈阴性。这只猫有轻微的呼吸和消化症状。血清学分析证实，在相隔10天的两份血清样本中都存在针对SARS-CoV-2的抗体。基因组序列分析显示，猫SARS-CoV-2与大多数法国人SARS-CoV-2一样，属于A2a进化支。本研究首次报道了法国（巴黎附近）猫的自然感染，可能是通过它们的主人。目前没有证据表明猫会传播COVID-19，主人不应该抛弃他们的宠物或损害它们的福利。
After its first description in Wuhan (China), SARS-CoV-2 the agent of coronavirus disease 2019 (COVID-19) rapidly spread worldwide. Previous studies suggested that pets could be susceptible to SARS-CoV-2. Here, we investigated the putative infection by SARS-CoV-2 in 22 cats and 11 dogs from owners previously infected or suspected of being infected by SARS-CoV-2. For each animal, rectal, nasopharyngeal swabs and serum were taken. Swabs were submitted to RT-qPCR assays targeting 2 genes of SARS-CoV-2. All dogs were tested SARS-CoV-2 negative. One cat was tested positive by RT-qPCR on rectal swab. Nasopharyngeal swabs from this animal were tested negative. This cat showed mild respiratory and digestive signs. Serological analysis confirms the presence of antibodies against the SARS-CoV-2 in both serum samples taken 10 days apart. Genome sequence analysis revealed that the cat SARS-CoV-2 belongs to the phylogenetic clade A2a like most of the French human SARS-CoV-2. This study reports for the first time the natural infection of a cat in France (near Paris) probably through their owners. There is currently no evidence that cats can spread COVID-19 and owners should not abandon their pets or compromise their welfare.