Gastrointestinal symptoms before and during menses in women with IBD
Gastrointestinal symptoms before and during menses in women with IBD
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DOI：
10.1111/j.1365-2036.2012.05155.x
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发表时间：
2012-07-01
影响因子：
7.6
通讯作者：
Avery, L.
中科院分区：
文献类型：
--
作者：
Bernstein, M. T.;Graff, L. A.;Avery, L.
研究背景：人们认为患有炎症性肠病（IBD）的女性在月经前后症状加重。然而，关于规范变化和与月经有关的症状出现的信息很少。目的在以人群为基础的IBD女性与健康女性队列中确定胃肠道和其他症状与月经之间的关系。方法在曼尼托巴大学IBD研究登记处登记的年龄在18岁至65岁之间的妇女通过邮寄方式进行调查。通过妇科门诊诊所招募成年妇女作为对照组。参与者被要求考虑最近几个月的月经期，并报告与月经前和月经期间相似的症状。结果绝经前妇女克罗恩病（CD） 151例，溃疡性结肠炎（UC） 87例，绝经前对照组156例。在所有三个队列中，月经发作的平均年龄相似，每组月经规律的百分比相似。经前腹痛在UC（36.8%）中较CD （51%， P相似= 0.034）和对照组（57.6%，P相似= 0.002）少。经前腹泻和月经期间腹泻在CD组（分别为47.7%和59.6%）比UC组（26.4% P相似= 0.001和42.5%，P相似= 0.01）和对照组（24.4%，P相似= 0.01）更常见
Background It is believed that women with inflammatory bowel disease (IBD) have heightened symptoms around their menses. However, there is little information regarding normative changes and which symptoms emerge in relation to menses. Aim To determine the relationship between gastrointestinal and other symptoms and menses in a population-based cohort of women with IBD vs. healthy women. Methods Women enrolled in the University of Manitoba IBD Research Registry who were between 18 and 65 similar to years were mailed a survey. A control group of adult women were recruited through out-patient gynaecology clinics. Participants were asked to consider their menstrual periods in the recent several months and report on symptoms 15 similar to days prior to and during the days of their menses. Results There were 151 premenopausal women with Crohn's disease (CD), 87 with ulcerative colitis (UC) and 156 premenopausal controls. Mean age of menses onset was similar in all three cohorts and the percentage in each group with regular menstrual periods was similar. Premenstrually, abdominal pain was less commonly reported in UC (36.8%) than CD (51%, P similar to=similar to 0.034) and controls (57.6%, P similar to=similar to 0.002). Premenstrually, and during menses diarrhoea was more commonly reported in CD (47.7% and 59.6% respectively) than UC (26.4% P similar to=similar to 0.001 and 42.5%, P similar to=similar to 0.01 respectively) and controls (24.4%, P similar to