Characterizing mechanism-based pain phenotypes in patients with chronic pancreatitis: a cross-sectional analysis of the PROspective Evaluation of Chronic Pancreatitis for EpidEmiologic and Translational StuDies.
Characterizing mechanism-based pain phenotypes in patients with chronic pancreatitis: a cross-sectional analysis of the PROspective Evaluation of Chronic Pancreatitis for EpidEmiologic and Translational StuDies.
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DOI：
10.1097/j.pain.0000000000002710
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发表时间：
2023-02-01
期刊：
影响因子：
7.4
通讯作者：
中科院分区：
文献类型：
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作者：
这是第一份报告的特点分布的疼痛表型在慢性胰腺炎使用PROMIS伤害性和神经性疼痛的质量工具。疼痛在慢性胰腺炎（CP）中很常见，并严重降低生活质量（QoL）。多种潜在机制导致异质性疼痛体验并降低疼痛管理的有效性。本研究旨在描述疼痛性CP中基于机制的疼痛表型的分布特征。收集分析的数据作为流行病学和转化研究慢性胰腺炎前瞻性评价的一部分，这是一项由NCI/NIDDK资助的慢性胰腺炎自然史纵向研究。慢性胰腺炎的流行病学和转化研究的前瞻性评价包括疼痛、药物使用、总体健康和QoL的患者报告结局（PRO）指标。在CP受试者（N = 681）中，80%在入组前一年内发生腹痛。在入组前一周内经历疼痛的受试者（N = 391）完成PROMIS神经性和伤害性疼痛质量工具，然后用于按疼痛类型对其进行分类：40%为伤害性疼痛，5%为神经性疼痛，32%为两种类型的疼痛。在女性和糖尿病患者中，两种类型疼痛的患病率较高，而在男性和胰管狭窄患者中，单纯伤害性疼痛更为普遍。其他因素，包括止痛药的使用和医疗保健的利用，在基于疼痛类型的组之间没有差异。两组受试者的健康状况和生活质量评分均显著低于单纯伤害感受性疼痛的受试者，这表明使用社会心理疼痛调查可能有助于了解CP患者的疼痛亚型。需要进行更多的研究，以确定可能与特定机制干预措施相关并预测其反应的生化和生物物理特征。
This is the first report characterizing the distribution of pain phenotypes in chronic pancreatitis using the PROMIS Nociceptive and Neuropathic Pain Quality instruments. Pain is common in chronic pancreatitis (CP) and profoundly reduces quality of life (QoL). Multiple underlying mechanisms contribute to a heterogenous pain experience and reduce efficacy of pain management. This study was designed to characterize the distribution of mechanism-based pain phenotypes in painful CP. The data analyzed were collected as part of the PROspective Evaluation of Chronic Pancreatitis for EpidEmiologic and Translational StuDies, an NCI/NIDDK-funded longitudinal study of the natural history of CP. The PROspective Evaluation of Chronic pancreatitis for EpidEmiologic and translational stuDies includes patient-reported outcome (PRO) measures of pain, medication use, global health, and QoL. Of subjects (N = 681) with CP, 80% experienced abdominal pain within the year before enrollment. Subjects who experienced pain in the week before enrollment (N = 391) completed PROMIS Neuropathic and Nociceptive Pain Quality instruments which were then used to classify them by pain type: 40% had nociceptive, 5% had neuropathic-like, and 32% had both types of pain. The prevalence of having both types of pain was higher among women and subjects with diabetes mellitus, whereas nociceptive-only pain was more prevalent among men and those with pancreatic duct stricture. Other factors, including pain medication use and healthcare utilization, did not differ between groups based on pain type. Subjects in the Both group had significantly worse health and QoL scores relative to those with nociceptive-only pain, suggesting that using psychosocial pain surveys may be useful for understanding pain subtypes in patients with CP. Additional research is needed to identify biochemical and biophysical signatures that may associate with and predict responses to mechanism-specific interventions.
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DOI：
10.1007/s13311-020-00887-6
发表时间：
2020-07
期刊：
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
影响因子：
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作者：
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DOI：
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期刊：
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影响因子：
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作者：
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通讯作者：
Pancreatic Quantitative Sensory Testing (P-QST) Consortium
影响因子：
4.8
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影响因子：
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