Pathological and therapeutic interactions between bacteriophages, microbes and the host in inflammatory bowel disease
Pathological and therapeutic interactions between bacteriophages, microbes and the host in inflammatory bowel disease
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DOI：
10.3748/wjg.v21.i40.11321
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发表时间：
2015-10-28
影响因子：
4.3
通讯作者：
Gardlik, Roman
中科院分区：
文献类型：
--
作者：
Babickova, Janka;Gardlik, Roman
肠道微生物群是宿主与其微生物相互作用的动态系统。在生理条件下，存在一种良好的平衡和互利关系。这种平衡的破坏是炎症性肠病（IBD）的标志。微生物组的改变是IBD的结果还是原因目前还不完全清楚。IBD的发病机制被认为是遗传易感性、免疫系统和环境因素之间复杂的相互作用。近年来，对人类微生物组的宏基因组研究提供了有用的数据，有助于解开IBD之谜。在这篇综述中，我们总结和讨论了目前关于IBD肠道菌群组成、宿主-微生物相互作用和利用细菌治疗IBD的可能性的知识。此外，本文还对噬菌体在IBD发病机制和治疗中的可能作用进行了展望。
The intestinal microbiome is a dynamic system of interactions between the host and its microbes. Under physiological conditions, a fine balance and mutually beneficial relationship is present. Disruption of this balance is a hallmark of inflammatory bowel disease (IBD). Whether an altered microbiome is the consequence or the cause of IBD is currently not fully understood. The pathogenesis of IBD is believed to be a complex interaction between genetic predisposition, the immune system and environmental factors. In the recent years, metagenomic studies of the human microbiome have provided useful data that are helping to assemble the IBD puzzle. In this review, we summarize and discuss current knowledge on the composition of the intestinal microbiota in IBD, host-microbe interactions and therapeutic possibilities using bacteria in IBD. Moreover, an outlook on the possible contribution of bacteriophages in the pathogenesis and therapy of IBD is provided.