United We Stand; Divided We Fibrillate?
United We Stand; Divided We Fibrillate?
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团结就是力量;
DOI：
10.1161/circresaha.117.312176
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发表时间：
2017
影响因子：
20.1
通讯作者：
London,Barry
中科院分区：
文献类型：
--
作者：
London,Barry
伦敦心脏稳定性通过连接1303进展。这些细胞的分子特征是什么？为什么它们比其他细胞更脆弱？我们能否针对这些细胞进行治疗以减缓心力衰竭的进展？当其他心力衰竭疗法生效时，增加这些细胞与其邻居的偶联是否有助于支持它们？20世纪70年代一首流行的摇滚歌曲的歌词说：“你可以走自己的路，走自己的路，你可以称之为，另一个孤独的一天。[13]在Lang等人的文章中，[11]他们似乎已经确定了一群心肌细胞正在这样做，并因此增加了心脏的电脆弱性。心脏的一个主要优势在于其连通性，在很大程度上由间隙连接介导，间隙连接在疾病（如心力衰竭）的背景下可能会失败。整体确实大于各部分之和。也许，从合胞体中分离出来的一群肌细胞已经被识别出来，现在我们可以为了整体的利益而重新团结和连接它们。
London Cardiac Stability Through Connectivity 1303 progression. What is the molecular characterization of those cells, and why are they more vulnerable than others? Could we target treatments toward those cells to slow heart failure progression? Would increasing the coupling of those cells to their neighbors help to support them while other heart failure therapies take effect?The lyrics of a popular Rock-and-Roll song from the 1970s stated “You can go your own way, Go your own way, You can call it, Another lonely day.” 13 In the article by Lang et al, 11 they seem to have identified a population of cardiac myocytes doing just that and increasing the electric vulnerability of the heart as a result. A major strength of the heart lies in its connectivity, mediated to a significant extent by gap junctions that can fail in the setting of diseases, such as heart failure. The whole is truly greater than the sum of its parts. Perhaps, a population of myocytes seceding from the syncytium has been identified, and now we can work to reunite and reconnect them for the benefit of the whole.