Intrastriatal grafts of fetal ventral mesencephalon improve allodynia-like withdrawal response to mechanical stimulation in a rat model of Parkinson's disease
Intrastriatal grafts of fetal ventral mesencephalon improve allodynia-like withdrawal response to mechanical stimulation in a rat model of Parkinson's disease
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DOI：
10.1016/j.neulet.2014.05.007
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发表时间：
2014-06
影响因子：
2.5
通讯作者：
R. Takeda;Y. Ishida;Kosuke Ebihara;Hiroshi Abe;Hisae Matsuo;T. Ikeda;G. Koganemaru;A. Kuramashi;H. Funahashi;Y. Magata;K. Kawai;T. Nishimori
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作者：
R. Takeda;Y. Ishida;Kosuke Ebihara;Hiroshi Abe;Hisae Matsuo;T. Ikeda;G. Koganemaru;A. Kuramashi;H. Funahashi;Y. Magata;K. Kawai;T. Nishimori
我们之前报道过，帕金森病的单侧 6-羟基多巴胺 (6-OHDA) 大鼠模型对大鼠后爪同侧的机械刺激表现出异常性疼痛样戒断反应。本研究的目的是探讨胎儿腹侧中脑 (VM) 纹状体内移植物对 6-OHDA 大鼠戒断反应的影响。使用冯弗雷细丝测量对大鼠后爪机械刺激的反应的缩回阈值。在6-OHDA病灶同侧，VM移植的6-OHDA大鼠响应机械刺激的退缩阈值与假移植的大鼠相比显着增加，但移植后5周对侧没有变化。目前的结果表明，胎儿 VM 的纹状体内移植物可以减轻 6-OHDA 大鼠机械刺激引起的痛感。
We previously reported that a unilateral 6-hydroxydopamine (6-OHDA) rat model of Parkinson's disease showed allodynia-like withdrawal response to mechanical stimulation of the ipsilateral side of the rat hindpaw. The goal of this study was to investigate the effect of intrastriatal grafts of fetal ventral mesencephalon (VM) on the withdrawal response in 6-OHDA rats. The withdrawal threshold in response to the mechanical stimulation of the rat hindpaw was measured using von Frey filaments. In the ipsilateral side of the 6-OHDA lesions, the withdrawal threshold in response to mechanical stimulation significantly increased in 6-OHDA rats with VM grafts compared with those with sham grafts, but did not change in the contralateral side at 5 weeks after transplantation. The present results suggest that the intrastriatal grafts of fetal VM may relieve pain sensation induced by mechanical stimulation in 6-OHDA rats.