THE CAENORHABDITIS-ELEGANS HETEROCHRONIC GENE LIN-14 ENCODES A NUCLEAR-PROTEIN THAT FORMS A TEMPORAL DEVELOPMENTAL SWITCH
THE CAENORHABDITIS-ELEGANS HETEROCHRONIC GENE LIN-14 ENCODES A NUCLEAR-PROTEIN THAT FORMS A TEMPORAL DEVELOPMENTAL SWITCH
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DOI：
10.1038/338313a0
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发表时间：
1989-03-23
期刊：
影响因子：
64.8
通讯作者：
GIUSTO, J
中科院分区：
文献类型：
--
作者：
RUVKUN, G;GIUSTO, J
在野生型发育过程中，线虫的一种蛋白产物--teganhabditis elegansheterochronic genelin-14定位于胚胎和早期幼虫的特定体细胞的细胞核，但在晚期幼虫和成体索马体中不存在。功能获得性lin-14突变导致lin-14蛋白水平在整个发育过程中保持高水平，导致早期细胞谱系的发育退化。正常下调的thelin-14核蛋白水平编码了早期和晚期细胞命运之间的时间转换。
During wild-type development, a protein product of theCaenorhabditis elegansheterochronic genelin-14is localized to nuclei of specific somatic cells in embryos and early larvae, but is absent in late larvae and adult soma. Gain-of-functionlin-14mutations cause the level oflin-14protein to remain high throughout development, resulting in developmental reiterations of early cell lineages. The normal down-regulation of thelin-14nuclear protein level encodes a temporal switch between early and late cell fates.