Autophagy and disease: always two sides to a problem.
Autophagy and disease: always two sides to a problem.
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DOI：
10.1002/path.3025
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发表时间：
2012-01
影响因子：
7.3
通讯作者：
Cuervo, Ana Maria
中科院分区：
文献类型：
--
作者：
Sridhar, Sunandini;Botbol, Yair;Macian, Fernando;Cuervo, Ana Maria
关键词：
自噬是传统上已知的通过去除溶酶体中的细胞内组分来有助于细胞清洁的过程。近年来，对自噬在分子水平上的深入研究也有助于扩大我们对这一途径生理作用的理解。除了在质量控制中的良好表征的作用之外，自噬已被证明在维持细胞内稳态和能量平衡、细胞和组织重塑以及细胞防御细胞外损伤和病原体中是重要的。这并不奇怪，鉴于越来越多的生理功能，自噬功能障碍和人类病理学之间的联系也得到了加强。在这篇综述中，我们关注与自噬中的原发性或继发性缺陷相关的几种病理条件，并评论其中许多人反复出现的主题，即自噬通常可以对疾病的进展产生有益和加重的影响。当考虑在许多这些病理条件下自噬的药理学调节的潜在治疗意义时，阐明决定疾病中自噬的这些双重功能之间的切换的因素已成为优先事项。
Autophagy is a process traditionally known to contribute to cellular cleaning through the removal of intracellular components in lysosomes. In recent years, the intensive scrutiny that autophagy has been subjected to at the molecular level, has also contributed to expand our understanding of the physiological role of this pathway. Added to the well-characterized role in quality control, autophagy has proven important in the maintenance of cellular homeostasis and of the energetic balance, in cellular and tissue remodeling and in the cellular defense against extracellular insults and pathogens. It is not a surprise that in light of this growing number of physiological functions, connections between autophagic malfunctioning and human pathologies have also been strengthened. In this review, we focus on several pathological conditions associated to primary or secondary defects in autophagy, and comment on a recurring theme for many of them, that is the fact that autophagy can often exert both beneficial and aggravating effects on the progression of disease. Elucidating the factors that determine the switch between these dual functions of autophagy in disease has become a priority when considering the potential therapeutic implications of the pharmacological modulation of autophagy in many of these pathological conditions.
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神经元中的自噬诱导和自噬体清除：与阿尔茨海默氏病自噬病理学的关系。
影响因子：
5.3
作者：
Boland, Barry;Kumar, Asok;Lee, Sooyeon;Platt, Frances M.;Wegiel, Jerzy;Yu, W. Haung;Nixon, Ralph A.
通讯作者：
Nixon, Ralph A.
DOI：
10.1083/jcb.137.4.825
发表时间：
1997-05-19
期刊：
The Journal of cell biology
影响因子：
--
作者：
Agarraberes FA;Terlecky SR;Dice JF
通讯作者：
Dice JF
影响因子：
5.3
作者：
Bandyopadhyay, Urmi;Kaushik, Susmita;Cuervo, Ana Maria
通讯作者：
Cuervo, Ana Maria
影响因子：
10.9
作者：
Cuervo, Ana Maria
通讯作者：
Cuervo, Ana Maria
影响因子：
5.6
作者：
Cao, Dian J.;Gillette, Thomas G.;Hill, Joseph A.
通讯作者：
Hill, Joseph A.