Role of PPARgamma in macrophage biology and atherosclerosis.
Role of PPARgamma in macrophage biology and atherosclerosis.
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PPARgamma 在巨噬细胞生物学和动脉粥样硬化中的作用。
DOI：
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发表时间：
2004
影响因子：
10.9
通讯作者：
A. Chawla
中科院分区：
文献类型：
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作者：
Lina Zhang;A. Chawla
巨噬细胞通过保护宿主免受微生物入侵和清除内源性细胞碎片来发挥关键功能。对于识别、吞噬和清除病原体至关重要的分子也介导致病性脂蛋白的摄取和降解。例如，在动脉粥样硬化形成过程中，清除被捕获的脂蛋白会导致泡沫细胞的形成，并随后激活这些富含脂质的巨噬细胞。尽管它们最初在临床上是无声的，但这些脂肪条纹会演变成复杂的炎症斑块，导致显着的发病率和死亡率。因此，减少泡沫细胞形成和减少巨噬细胞炎症反应的干预措施可能成为冠状动脉疾病的有效疗法。噻唑烷二酮类 (TZD) 作为过氧化物酶体增殖物激活受体-γ (PPARgamma) 配体的作用可能被开发为抗动脉粥样硬化药物。
Macrophages carry out key functions by defending a host from microbial invaders and by clearing endogenous cellular debris. Molecules that are essential for the recognition, phagocytosis and clearance of pathogens also mediate the uptake and degradation of pathogenic lipoproteins. During atherogenesis, for example, scavenging trapped lipoproteins leads to the formation of foam cells and subsequently the activation of these lipid-laden macrophages. Although they are initially clinically silent, these fatty streaks evolve into complex inflammatory plaques that cause significant morbidity and mortality. Thus, interventions that decrease foam cell formation and reduce the inflammatory response of macrophages could become effective therapies for coronary artery disease. Thiazolidinediones (TZDs) might be developed as anti-atherogenic agents on the basis of their actions as ligands for peroxisome proliferator-activated receptor-gamma (PPARgamma).