Diversity and relatedness among the type I Interferons
Diversity and relatedness among the type I Interferons
复制标题
DOI：
10.1089/jir.2004.24.687
复制
发表时间：
2004-12-01
影响因子：
2.3
通讯作者：
Fish, EN
中科院分区：
文献类型：
--
作者：
Chen, JB;Baig, E;Fish, EN
I 型干扰素 (IFN) 包括 IFN-α 家族亚型、IFN-β、IFN-omega、IFN-tau、IFN-κ、IFN-lambda 和 IFN-zeta。 IFN 基因缺乏内含子，编码分泌信号肽序列，在从细胞分泌之前被蛋白水解切割。与人IFN-α亚型之间大约50%的氨基酸序列同一性相反，人IFN-α与人IFN-β具有大约22%的同一性，与人IFN-omega具有大约37%的同一性。 I 型干扰素中的许多保守残基与受体识别和结构完整性有关。本报告提供了分别位于 4 号和 9 号染色体上的小鼠和人类 IFN 基因簇的基因注释的更新，以及随附的氨基酸序列比对。基于序列同一性，还提出了不同哺乳动物 I 型 IFN 的系统发育树分析，显示了这些 IFN 之间的高度相关性。值得注意的是，不同人和小鼠 IFN 启动子区域的序列比对揭示了转录因子结合位点的不同特征模式，这意味着不同的诱导剂可能会差异性地激活不同 IFN 的转录。
Type I interferons (IFNs) include the IFN-alpha family of subtypes, IFN-beta, IFN-omega, IFN-tau, IFN-kappa, IFN-lambda, and IFN-zeta. IFN genes lack introns and encode secretory signal peptide sequences that are proteolytically cleaved prior to secretion from the cell. In contrast to the approximately 50% amino acid sequence identity among the human IFN-alpha subtypes, human IFN-alphas share approximately 22% identity with human IFN-beta and 37% identity with human IFN-omega. Many of the conserved residues among the type I IFNs are implicated in receptor recognition and structural integrity. This report provides an update on the gene annotations for the mouse and human IFN gene clusters on chromosome 4 and 9, respectively, with accompanying amino acid sequence alignments. Based on sequence identities, a phylogenic tree analysis for the different mammalian Type I IFNs is also presented, showing the high degree of relatedness among these IFNs. Notably, sequence alignment of the different human and mouse IFN promoter regions reveals different signature patterns for transcription factor binding sites, implying different inducers might differentially activate the transcription of the different IFNs.