MicroRNA control of vascular endothelial growth factor signaling output during vascular development.
MicroRNA control of vascular endothelial growth factor signaling output during vascular development.
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DOI：
10.1161/atvbaha.112.300142
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发表时间：
2013-02
期刊：
影响因子：
--
通讯作者：
Fish JE
中科院分区：
文献类型：
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作者：
Dang LT;Lawson ND;Fish JE
内皮细胞(ECs)对环境中信号的调节反应不仅对早期发育过程中原始血管网络的从头形成(即血管生成)至关重要，而且对随后新血管的生长和重建(即血管生成)也是必需的。血管内皮生长因子(VEGFs)及其内皮细胞特异性受体在血管生长的各个方面都起着至关重要的作用。这些通路的输出如何影响和协调内皮细胞的行为是一个深入研究的领域。最近，许多研究强调了microRNAs在几种不同环境中调节血管内皮生长因子信号输出的作用。在这篇综述中，我们将提供关于小RNA如何调控血管内皮生长因子信号通路的多个方面的概述。特别是，我们强调了识别microRNAs及其靶点提供了对下游效应因子在发育过程中调节血管内皮生长因子输出的作用的新见解。由于血管内皮生长因子在血管内皮细胞生物学的多个方面发挥着广泛的作用，并已成为病理性血管生长的治疗靶点，因此影响血管内皮生长因子信号输出的microRNAs无疑将成为具有临床价值的主要靶点。
The regulated response of endothelial cells (ECs) to signals in their environment is not only critical for the de novo formation of primordial vascular networks during early development (i.e. vasculogenesis), but is also required for the subsequent growth and remodelling of new blood vessels from pre-existing ones (i.e. angiogenesis). Vascular endothelial growth factors (Vegfs) and their endothelial-cell specific receptors play a crucial role in nearly all aspects of blood vessel growth. How the outputs from these pathways affect and coordinate endothelial behaviour is an area of intense research. Recently, numerous studies have highlighted roles for microRNAs in modulating Vegf signalling output in several different contexts. In this review we will provide an overview of how small RNAs regulate multiple aspects of the Vegf signalling pathway. In particular, we highlight areas where identification of microRNAs and their targets has provided new insight into the role of downstream effectors in modulating Vegf output during development. Since Vegf plays a broad role in multiple aspects of endothelial biology and has become a target for therapeutic manipulation of pathological blood vessel growth, microRNAs that affect Vegf signalling output will undoubtedly be major targets of clinical value.