Dynamics of prestressed semiflexible polymer chains as a model of cell rheology.
Dynamics of prestressed semiflexible polymer chains as a model of cell rheology.
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作为细胞流变学模型的预应力半柔性聚合物链动力学。
DOI：
10.1103/physrevlett.97.168101
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发表时间：
2006
影响因子：
8.6
通讯作者：
Stamenović,Dimitrije
中科院分区：
文献类型：
--
作者：
Rosenblatt,Noah;Alencar,AdrianoM;Majumdar,Arnab;Suki,Béla;Stamenović,Dimitrije
我们报告了一个预应力非线性半柔性聚合物链模型，该模型将热驱动动力学与活细胞的蠕变行为联系起来。数值模拟表明，链条的蠕变遵循幂律，其指数随着预应力的增加而减小。这与响应拉伸而通过链条传播自由能有关，其中传播速度通过链条的非线性弹性由预应力调节。这些结果表明细胞流变学的主要方面与张力下单聚合物链的动力学一致。
We report on a model of a prestressed nonlinear semiflexible polymer chain that links thermally driven dynamics to the creep behavior of living cells. Numerical simulations show that the chain’s creep follows a power law with an exponent that decreases with increasing prestress. This is related to the propagation of free energy through the chain in response to stretching, where the propagation speed is regulated by the prestress via the chain’s nonlinear elasticity. These results indicate that the main aspects of cell rheology are consistent with the dynamics of single polymer chains under tension.