Glial fibrillary acidic protein is elevated in superior frontal, parietal and cerebellar cortices of autistic subjects
Glial fibrillary acidic protein is elevated in superior frontal, parietal and cerebellar cortices of autistic subjects
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DOI：
10.1080/14734220500208846
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发表时间：
2005-09-01
期刊：
影响因子：
3.5
通讯作者：
Fatemi, SH
中科院分区：
文献类型：
--
作者：
Laurence, JA;Fatemi, SH
自闭症是一种儿童早期衰弱的神经发育障碍，有遗传和环境两方面的原因。免疫系统失调被认为与这种紊乱有关。我们使用SDS-PAGE和Western blotting技术对年龄匹配的自闭症患者和对照组尸检标本中大脑的三个区域，即第9区、第40区和小脑中的胶质纤维酸性蛋白(GFAP)和β-肌动蛋白的水平进行了量化。自闭症患者的三个脑区的GFAP水平均显著升高。这份报告证实了最近的一份报告，该报告显示自闭症患者的小胶质细胞和星形胶质细胞激活。自闭症患者大脑中GFAP水平的升高意味着胶质增生、反应性损伤和神经元迁移过程受扰。
Autism is a debilitating neurodevelopmental disorder of early childhood with both genetic and environmental origins. Immune system dysregulation has been hypothesized to be involved in this disorder. We quantified levels of glial fibrillary acidic protein (GFAP) and beta-actin in three areas of the brain, namely, area 9, area 40 and cerebellum, in age matched autistic and control postmortem specimen using SDS-PAGE and western blotting techniques. Significant elevations in levels of GFAP were observed in all three brain areas in autism. This report confirms a recent report showing microglial and astroglial activation in autism. Increased GFAP levels in autistic brains signify gliosis, reactive injury, and perturbed neuronal migration processes.