Carotid Occlusion Accentuates Aortic Stenosis and Cardiac Remodeling With Preserved Systolic Function in LDL Receptor-Deficient Mice.
Carotid Occlusion Accentuates Aortic Stenosis and Cardiac Remodeling With Preserved Systolic Function in LDL Receptor-Deficient Mice.
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颈动脉闭塞加剧了 LDL 受体缺陷小鼠的主动脉瓣狭窄和心脏重塑，并保留了收缩功能
DOI：
10.3389/fphys.2020.578722
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发表时间：
2020
影响因子：
4
通讯作者：
Qu L
中科院分区：
文献类型：
--
作者：
Liu Y;Cai J;Qu L
背景：颈动脉粥样硬化性疾病与主动脉狭窄和心功能减退有关。颈动脉和心脏病理之间的因果关系尚不清楚。我们旨在探讨颈动脉狭窄或闭塞对心脏病理和功能的影响。方法和结果：我们用150或300μ的串联手术或假手术在36只致动脉粥样硬化的小鼠身上制造了颈动脉阻塞或狭窄。通过组织学和动物超声评价心脏的结构和功能。与对照组相比，150-μ-m组的主动脉根部斑块负荷更大，瓣叶更厚。此外，与对照组相比，两组手术组的左室后壁厚度更厚，内径更小。尽管与对照组相比，手术组保留了收缩功能，但与对照组相比，150-μ-m组也发现心肌纤维化增加。结论：在小鼠模型中，颈动脉阻断加重了主动脉狭窄的形成，并促进了心室重构，而不损害收缩功能。颈动脉粥样硬化斑块可能是主动脉狭窄和心室重构的致病因素之一。
Background: Carotid atherosclerotic disease is associated with aortic stenosis and reduced cardiac function. The causality between carotid and cardiac pathologies is unknown. We aim to explore the effects of carotid stenosis or occlusion on cardiac pathology and function. Methods and Results: We produced carotid obstruction or stenosis in 36 atherogenic mice with 150- or 300-μm tandem surgery or sham surgery. The structure and function of the heart were assessed by histology and animal ultrasound. The 150-μm group had larger plaque burden and thicker valve leaflets in the aortic root than did the control group. Also, the two surgery groups had a thicker left ventricular posterior wall and smaller internal diameter compared with controls. Increased myocardial fibrosis was also found in the 150-μm group compared with controls, although the surgery groups had preserved systolic function compared with that of controls. Conclusions: In a mouse model, carotid occlusion accentuated the formation of aortic stenosis and promoted ventricular remodeling without impairing systolic function. Carotid atherosclerotic plaque may be a pathogenic factor for aortic stenosis and ventricular remodeling.
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DOI：
10.1056/nejmoa0912321
发表时间：
2010-07-01
期刊：
The New England journal of medicine
影响因子：
--
作者：
Brott TG;Hobson RW 2nd;Howard G;Roubin GS;Clark WM;Brooks W;Mackey A;Hill MD;Leimgruber PP;Sheffet AJ;Howard VJ;Moore WS;Voeks JH;Hopkins LN;Cutlip DE;Cohen DJ;Popma JJ;Ferguson RD;Cohen SN;Blackshear JL;Silver FL;Mohr JP;Lal BK;Meschia JF;CREST Investigators
通讯作者：
CREST Investigators
影响因子：
18.2
作者：
Hedberg, Par;Hammar, Charlotta;Henriksen, Egil
通讯作者：
Henriksen, Egil
DOI：
10.1111/echo.14672
发表时间：
2020-04-29
影响因子：
1.5
作者：
Karaduman, Bilge Duran;Ayhan, Huseyin;Bozkurt, Engin
通讯作者：
Bozkurt, Engin
影响因子：
14
作者：
Lee, Hyun-Jung;Lee, Heesun;Lee, Seung-Pyo
通讯作者：
Lee, Seung-Pyo
影响因子：
20.1
作者：
Bentzon, Jacob Fog;Otsuka, Fumiyuki;Falk, Erling
通讯作者：
Falk, Erling