Complementary regulation of early B-lymphoid differentiation by genetic and epigenetic mechanisms.
Complementary regulation of early B-lymphoid differentiation by genetic and epigenetic mechanisms.
复制标题
通过遗传和表观遗传机制对早期 B 淋巴分化进行补充调节。
DOI：
10.1007/s12185-013-1424-7
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Kanakura Y.
中科院分区：
文献类型：
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作者：
Yokota T;Sudo T;Ishibashi T;Doi Y;Ichii M;Orirani K;Kanakura Y.
虽然B淋巴细胞生成是细胞分化中最好定义的范例之一，但我们对其最早过程（造血干细胞（HSC）进入B谱系）的调控机制的了解有限。然而，最近在分选祖细胞和监测其表观遗传特征的方法学进展增加了我们对HSC活动的理解。现在已知，即使是高度富集的HSC组分在淋巴细胞生成潜能方面也是异质的。虽然表面标记物和报告蛋白提供了B系祖细胞顺序分化的信息，但转录因子之间的复杂相互作用也已被证明在此过程中发挥重要作用。组蛋白、核小体和染色质的表观遗传调控似乎在这个复杂的转录网络中起着至关重要的背景作用。在这篇综述中，我们总结了最近的研究结果的生理过程中的早期B系分化，这提供了一个新的范式，了解和谐的行动，遗传和表观遗传机制。
Although B lymphopoiesis is one of the best-defined paradigms in cell differentiation, our knowledge of the regulatory mechanisms underlying its earliest processes, in which hematopoietic stem cells (HSCs) enter the B lineage, is limited. However, recent methodological advances in sorting progenitor cells and monitoring their epigenetic features have increased our understanding of HSC activities. It is now known that even the highly enriched HSC fraction is heterogeneous in terms of lymphopoietic potential. While surface markers and reporter proteins provide information on the sequential differentiation of B-lineage progenitors, complex interactions between transcription factors have also been shown to play a major role in this process. Epigenetic regulation of histones, nucleosomes, and chromatin appears to play a crucial background role in this elaborate transcription network. In this review, we summarize recent findings on the physiological processes of early B-lineage differentiation, which provides a new paradigm for understanding the harmonious action of genetic and epigenetic mechanisms.